Hidehiro Iida
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ

Professor, PET Basic Operations (Turku PET Centre)

hidehiro.iida@utu.fi







Areas of expertise
Instrumentation and modeling in PET, SPECT and medical imaging

Biography

Dr.
Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.  



Research

Dr.
Hidehiro Iida’s primary interest is the non-invasive imaging of
bio-physiological functions and molecular processes using PET, SPECT and MRI modalities.
He has been working on instrumentation and kinetic modeling-based
methodologies. and contributed to develop several methods to quantitatively
assess tissue perfusion, oxidative metabolism and other functions, in brain,
heart and other organs. Some of those techniques have been utilized in a number
of clinical researches as a gold standard, and also in clinical practice in
patients with cerebral and cardiovascular diseases.



Teaching

Interest areas in teaching are as follows:

1. PET, SPECT and MR instrumentation

2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem

3. To learn pathophysiology from PET, SPECT and MR images.  



Publications
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Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans (2016)
Journal of the American Heart Association
Hattori Y, Enmi J, Iguchi S, Saito S, Yamamoto Y, Tsuji M, Nagatsuka K, Kalaria RN, Iida H, Ihara M
(
A1 Journal article – refereed)

High amyloid-beta deposition related to depressive symptoms in older individuals with normal cognition: a pilot study (2016)
International Journal of Geriatric Psychiatry
Yasuno F, Kazui H, Morita N, Kajimoto K, Ihara M, Taguchi A, Yamamoto A, Matsuoka K, Kosaka J, Kudo T, Iida H, Kishimoto T, Nagatsuka K
(
A1 Journal article – refereed)

Interhemispheric functional disconnection because of abnormal corpus callosum integrity in bipolar disorder type II (2016) Yasuno F, Kudo T, Matsuoka K, Yamamoto A, Takahashi M, Nakagawara J, Nagatsuka K, Iida H, Kishimoto T
(
A1 Journal article – refereed)

Reduction in camera-specific variability in [I-123]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls (2016)
European Journal of Nuclear Medicine and Molecular Imaging
Buchert R, Kluge A, Tossici-Bolt L, Dickson J, Bronzel M, Lange C, Asenbaum S, Booij J, Kapucu LOA, Svarer C, Koulibaly PM, Nobili F, Pagani M, Sabri O, Sera T, Tatsch K, Vander Borght T, Van Laere K, Varrone A, Iida H
(
A1 Journal article – refereed)

Substantial Reduction of Parenchymal Cerebral Blood Flow in Mice with Bilateral Common Carotid Artery Stenosis (2016)
Scientific Reports
Hattori Y, Enmi J, Iguchi S, Saito S, Yamamoto Y, Nagatsuka K, Iida H, Ihara M
(
A1 Journal article – refereed)

A Novel Mouse Model of Subcortical Infarcts with Dementia (2015) Hattori Y, Enmi J, Kitamura A, Yamamoto Y, Saito S, Takahashi Y, Iguchi S, Tsuji M, Yamahara K, Nagatsuka K, Iida H, Ihara M
(
A1 Journal article – refereed)

Combined PET/MRI: Multi-modality Multi-parametric Imaging Is Here (2015)
Molecular Imaging and Biology
Bailey DL, Pichler BJ, Guckel B, Barthel H, Beer AJ, Bremerich J, Czernin J, Drzezga A, Franzius C, Goh V, Hartenbach M, Iida H, Kjaer A, la Fougere C, Ladefoged CN, Law I, Nikolaou K, Quick HH, Sabri O, Schafer J, Schafers M, Wehrl HF, Beyer T, Beyer T
(
A1 Journal article – refereed)

Delayed atrophy in posterior cingulate cortex and apathy after stroke (2015)
International Journal of Geriatric Psychiatry
Matsuoka K, Yasuno F, Taguchi A, Yamamoto A, Kajimoto K, Kazui H, Kudo T, Sekiyama A, Kitamura S, Kiuchi K, Kosaka J, Kishimoto T, Iida H, Nagatsuka K
(
A1 Journal article – refereed)

Intraperitoneal and intravenous deliveries are not comparable in terms of drug efficacy and cell distribution in neonatal mice with hypoxia ischemia (2015)
Brain and Development
Ohshima M, Taguchi A, Tsuda H, Sato Y, Yamahara K, Harada-Shiba M, Miyazato M, Ikeda T, Iida H, Tsuji M
(
A1 Journal article – refereed)

Low amyloid-beta deposition correlates with high education in cognitively normal older adults: a pilot study (2015)
International Journal of Geriatric Psychiatry
Yasuno F, Kazui H, Morita N, Kajimoto K, Ihara M, Taguchi A, Yamamoto A, Matsuoka K, Kosaka J, Kudo T, Iida H, Kishimoto T, Nagatsuka K
(
A1 Journal article – refereed)

Resting-state synchrony between the retrosplenial cortex and anterior medial cortical structures relates to memory complaints in subjective cognitive impairment (2015)
Neurobiology of Aging
Yasuno F, Kazui H, Yamamoto A, Morita N, Kajimoto K, Ihara M, Taguchi A, Matsuoka K, Kosaka J, Tanaka T, Kudo T, Takeda M, Nagatsuka K, Iida H, Kishimoto T
(
A1 Journal article – refereed)

Adequacy of a compartment model for CMRO2 quantitation using O-15-labeled oxygen and PET: a clearance measurement of O-15-radioactivity following intracarotid bolus injection of O-15-labeled oxyhemoglobin on Macaca fascicularis (2014)
Journal of Cerebral Blood Flow and Metabolism
Iida H, Iguchi S, Teramoto N, Koshino K, Zeniya T, Yamamoto A, Kudomi N, Moriguchi T, Hori Y, Enmi J, Kawashima H, Shah NJ, Nakagawara J
(
A1 Journal article – refereed)

Effects of Magnetic Fields of up to 9.4 T on Resolution and Contrast of PET Images as Measured with an MR-BrainPET (2014)
PLoS ONE
Shah NJ, Herzog H, Weirich C, Tellmann L, Kaffanke J, Caldeira L, Kops ER, Qaim SM, Coenen HH, Iida H
(
A1 Journal article – refereed)

Long-Term/Bioinert Labeling of Rat Mesenchymal Stem Cells with PVA-Gd Conjugates and MRI Monitoring of the Labeled Cell Survival after Intramuscular Transplantation (2014)
Bioconjugate Chemistry
Tachibana Y, Enmi J, Agudelo CA, Iida H, Yamaoka T
(
A1 Journal article – refereed)

Microstructural abnormalities in white matter and their effect on depressive symptoms after stroke (2014)
Psychiatry Research: Neuroimaging
Yasuno F, Taguchi A, Yamamoto A, Kajimoto K, Kazui H, Sekiyama A, Matsuoka K, Kitamura S, Kiuchi K, Kosaka J, Kishimoto T, Iida H, Nagatsuka K
(
A1 Journal article – refereed)

Microstructural abnormality in white matter, regulatory T lymphocytes, and depressive symptoms after stroke (2014)
Psychogeriatrics
Yasuno F, Taguchi A, Yamamoto A, Kajimoto K, Kazui H, Kudo T, Kikuchi-Taura A, Sekiyama A, Kishimoto T, Iida H, Nagatsuka K
(
A1 Journal article – refereed)

Microstructural changes of the nucleus accumbens due to increase of estradiol level during menstrual cycle contribute to recurrent manic episodes-A single case study (2014)
Psychiatry Research: Neuroimaging
Matsuoka K, Yasuno F, Inoue M, Yamamoto A, Kudo T, Kitamura S, Okada K, Kiuchi K, Kosaka J, Iida H, Kishimoto T
(
A1 Journal article – refereed)

PET Quantification of Cerebral Oxygen Metabolism in Small Animals (2014)
ScientificWorld Journal
Temma T, Koshino K, Moriguchi T, Enmi J, Iida H
(
A1 Journal article – refereed)

Quantification of myocardial blood flow using Tl-201 SPECT and population-based input function (2014)
Annals of Nuclear Medicine
Koshino K, Fukushima K, Fukumoto M, Hori Y, Moriguchi T, Zeniya T, Nishimura Y, Kiso K, Iida H
(
A1 Journal article – refereed)


Last updated on 2019-21-01 at 16:04