Hidehiro Iida
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ

Professor, PET Basic Operations (Turku PET Centre)

hidehiro.iida@utu.fi







Areas of expertise
Instrumentation and modeling in PET, SPECT and medical imaging

Biography

Dr.
Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.  



Research

Dr.
Hidehiro Iida’s primary interest is the non-invasive imaging of
bio-physiological functions and molecular processes using PET, SPECT and MRI modalities.
He has been working on instrumentation and kinetic modeling-based
methodologies. and contributed to develop several methods to quantitatively
assess tissue perfusion, oxidative metabolism and other functions, in brain,
heart and other organs. Some of those techniques have been utilized in a number
of clinical researches as a gold standard, and also in clinical practice in
patients with cerebral and cardiovascular diseases.



Teaching

Interest areas in teaching are as follows:

1. PET, SPECT and MR instrumentation

2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem

3. To learn pathophysiology from PET, SPECT and MR images.  



Publications
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Development of matrix metalloproteinase-targeted probes for lung inflammation detection with positron emission tomography (2018)
Scientific Reports
Kondo N, Temma T, Aita K, Shimochi S, Koshino K, Senda M, Iida H
(
A1 Journal article – refereed)

Dysregulation of RNF213 promotes cerebral hypoperfusion (2018)
Scientific Reports
Morimoto T, Enmi J, Hattori Y, Iguchi S, Saito S, Harada KH, Okuda H, Mineharu Y, Takagi Y, Youssefian S, Iida H, Miyamoto S, Ihara M, Kobayashi H, Koizumi A
(
A1 Journal article – refereed)

Early Detection of Cerebral Infarction After Focal Ischemia Using a New MRI Indicator (2018)
Molecular Neurobiology
Nakajo, Y. ;Zhao, Q. ;Enmi, J. I. ;Iida, H. ;Takahashi, J. C. ;Kataoka, H. ;Yamato, K. ;Yanamoto, H.
(
A1 Journal article – refereed)

I-123-Labeled oxLDL Is Widely Distributed Throughout the Whole Body in Mice (2018) Nakano A, Kawashima H, Miyake Y, Zeniya T, Yamamoto A, Koshino K, Temma T, Fukuda T, Fujita Y, Kakino A, Kanaya S, Sawamura T, Iida H
(
A1 Journal article – refereed)

One-pot enzymatic synthesis of L-[3-C-11]lactate for pharmacokinetic analysis of lactate metabolism in rat brain (2018)
Nuclear Medicine and Biology
Temma T, Kawashima H, Kondo N, Yamazaki M, Koshino K, Iida H
(
A1 Journal article – refereed)

Superfine Magnetic Resonance Imaging of the Cerebrovasculature Using Self-Assembled Branched Polyethylene Glycol-Gd Contrast Agent (2018)
Macromolecular Bioscience
Atsushi Mahara, Jun‐ichiro Enmi, Yu‐I Hsu, Naoki Kobayashi, Yoshiaki Hirano, Hidehiro Iida, Tetsuji Yamaoka
(
A1 Journal article – refereed)

System evaluation of automated production and inhalation of O-15-labeled gaseous radiopharmaceuticals for the rapid O-15-oxygen PET examinations (2018)
EJNMMI Physics
Satoshi Iguchi, Tetsuaki Moriguchi, Makoto Yamazaki, Yuki Hori, Kazuhiro Koshino, Kazunori Toyoda, Jarmo Teuho, Saeka Shimochi, Yusuke Terakawa, Tetsuya Fukuda, Jun C. Takahashi, Jyoji Nakagawara, Shigehiko Kanaya, Hidehiro Iida
(
A1 Journal article – refereed)

The renal blood flow reserve in healthy humans and patients with atherosclerotic renovascular disease measured by positron emission tomography using [O-15]H2O (2018)
EJNMMI Research
Paivarinta J, Koivuviita N, Oikonen V, Iida H, Liukko K, Manner I, Loyttyniemi E, Nuutila P, Metsarinne K
(
A1 Journal article – refereed)

Vascular responses to abrupt blood flow change after bypass surgery for complex intracranial aneurysms (2018)
Acta Neurochirurgica
Kataoka H, Makino Y, Takanishi K, Kimura Y, Takamura K, Yagi T, Iguchi S, Yamamoto A, Iida H, Ogata S, Nishimura K, Nakamura M, Umezu M, Iihara K, Takahashi JC
(
A1 Journal article – refereed)

Binding of C-11-Pittsburgh compound-B correlated with white matter injury in hypertensive small vessel disease (2017)
Annals of Nuclear Medicine
Hashimoto T, Yokota C, Koshino K, Temma T, Yamazaki M, Iguchi S, Shimomura R, Uehara T, Funatsu N, Hino T, Minematsu K, Iida H, Toyoda K
(
A1 Journal article – refereed)

Influences of 3D PET scanner components on increased scatter evaluated by a Monte Carlo simulation (2017)
Physics in Medicine and Biology
Hirano Y, Koshino K, Iida H
(
A1 Journal article – refereed)

Microstructural Differences in the Corpus Callosum in Patients With Bipolar Disorder and Major Depressive Disorder (2017)
Journal of Clinical Psychiatry
Matsuoka K, Yasuno F, Kishimoto T, Yamamoto A, Kiuchi K, Kosaka J, Nagatsuka K, Iida H, Kudo T
(
A1 Journal article – refereed)

Sequential PET estimation of cerebral oxygen metabolism with spontaneous respiration of O-15-gas in mice with bilateral common carotid artery stenosis (2017)
Journal of Cerebral Blood Flow and Metabolism
Temma T, Yamazaki M, Miyanohara J, Shirakawa H, Kondo N, Koshino K, Kaneko S, Iida H
(
A1 Journal article – refereed)

Significant correlation between openness personality in normal subjects and brain myelin mapping with T1/T2-weighted MR imaging (2017)
Heliyon
Yasuno F, Kudo T, Yamamoto A, Matsuoka K, Takahashi M, Iida H, Ihara M, Nagatsuka K, Kishimoto T
(
A1 Journal article – refereed)

Use of T1-weighted/T2-weighted magnetic resonance ratio to elucidate changes due to amyloid beta accumulation in cognitively normal subjects (2017) Yasuno F, Kazui H, Morita N, Kajimoto K, Ihara M, Taguchi A, Yamamoto A, Matsuoka K, Takahashi M, Nakagawara J, Iida H, Kishimoto T, Nagatsuka K
(
A1 Journal article – refereed)

Association between chronic stress-induced structural abnormalities in Ranvier nodes and reduced oligodendrocyte activity in major depression (2016)
Scientific Reports
Miyata S, Taniguchi M, Koyama Y, Shimizu S, Tanaka T, Yasuno F, Yamamoto A, Iida H, Kudo T, Katayama T, Tohyama M
(
A1 Journal article – refereed)

A structural model of age, grey matter volumes, education, and personality traits (2016)
Psychogeriatrics
Kitamura S, Yasuno F, Yamamoto A, Kazui H, Kudo T, Matsuoka K, Kiuchi K, Kosaka J, Nagatsuka K, Iida H, Kishimoto T
(
A1 Journal article – refereed)

Cerebral blood flow and metabolism associated with cerebral microbleeds in small vessel disease (2016)
Annals of Nuclear Medicine
Hashimoto T, Yokota C, Koshino K, Shimomura R, Hino T, Moriguchi T, Hori Y, Uehara T, Minematsu K, Iida H, Toyoda K
(
A1 Journal article – refereed)

Development of in vivo tissue-engineered microvascular grafts with an ultra small diameter of 0.6 mm (MicroBiotubes): acute phase evaluation by optical coherence tomography and magnetic resonance angiography (2016)
Journal of Artificial Organs
Ishii D, Enmi J, Moriwaki T, Ishibashi-Ueda H, Kobayashi M, Iwana S, Iida H, Satow T, Takahashi JC, Kurisu K, Nakayama Y
(
A1 Journal article – refereed)

Effect of Attenuation Correction on Regional Quantification Between PET/MR and PET/CT: A Multicenter Study Using a 3-Dimensional Brain Phantom (2016)
Journal of Nuclear Medicine
Teuho J, Johansson J, Linden J, Hansen AE, Holm S, Keller SH, Delso G, Veit-Haibach P, Magota K, Saunavaara V, Tolvanen T, Teras M, Iida H
(
A1 Journal article – refereed)


Last updated on 2019-21-01 at 16:04

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