Santosh Lamichhane
PhD (Metabolomics)

Postdoctoral Researcher, Centre for Biotechnology (Turku Centre for Biotechnology)

santosh.lamichhane@utu.fi







Areas of expertise
Lipidomics/Metabolomics
Systems medicine
Gut metabolome
Multivariate data analysis


Biography

Santosh Lamichhane has interest and expertise to work in the interface between
metabolomics, microbiome, nutrition, and health (Type 1 diabetes & Cancer).  



Research

Santosh Lamichhane currently works as a Post-doctoral researcher, University of Turku ( Turku Center for biotechnology). Lamichhane's PhD project involved development of metabolomics platform to elucidate the effects of Ploydextrose (synthetic fiber) on activity of the gut microbiota both in vivo and in vitro in the colon. During his PhD Lamichhane visited Bio-system data analysis Group at University of Amsterdam to enhance his skills in Multivariate Data analysis. He completed his Master's in Molecular medicine from Norwegian University of Science and Technology, Trondheim, Norway. During his masters he had been working with cancer cell metabolism, in particular being focused on Breast tumor tissues.



Teaching

Supervision of visiting PhD student for metabolomics analysis of tissue sample (HRMAS-NMR) at Aarhus University.

Training of PhD and research students for NMR analysis, multivariate data analysis at Aarhus University.

Training PhD and master for HRMAS analysis at NTNU, Trondheim



Publications

Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes (2019) Lamichhane Santosh, Ahonen Linda, Dyrlund Thomas Spartholt, Dickens Alex M., Siljander Heli, Hyöty Heikki, Ilonen Jorma, Toppari Jorma, Veijola Riitta, Hyötyläinen Tuulia, Knip Mikael, Oresic Matej
(
A1 Journal article – refereed)

A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes (2018) Lamichhane S, Ahonen L, Dyrlund TS, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M
(
A1 Journal article – refereed)

An Overview of Metabolomics Data Analysis: Current Tools and Future Perspectives (2018) Comprehensive Analytical Chemistry Lamichhane S., Sen P., Dickens A., Hyötyläinen T., Orešič M.
(
B2 Book chapter)

Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP) (2018)
Scientific Reports
Santosh Lamichhane, Linda Ahonen, Thomas Sparholt Dyrlund, Esko Kemppainen, Heli Siljander, Heikki Hyöty, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Tuulia Hyötyläinen, Mikael Knip, Matej Oresic
(
A1 Journal article – refereed)

Gut metabolome meets microbiome: A methodological perspective to understand the relationship between host and microbe (2018)
Methods
Santosh Lamichhane, Partho Sen, Alex M.Dickens, Matej Orešič, Hanne Christine Bertram
(
A1 Journal article – refereed)

H-1 HR-MAS NMR-based metabolomics analysis for dry-fermented sausage characterization (2018)
Food Chemistry
Garcia-Garcia AB, Lamichhane S, Castejon D, Cambero MI, Bertram HC
(
A1 Journal article – refereed)

Metabolic Fate of C-13-Labeled Polydextrose and Impact on the Gut Microbiome: A Triple-Phase Study in a Colon Simulator (2018)
Journal of Proteome Research
Lamichhane S, Yde CC, Jensen HM, Morovic W, Hibberd AA, Ouwehand AC, Saarinen MT, Forssten SD, Wiebe L, Marcussen J, Bertelsen K, Meier S, Young JF, Bertram HC
(
A1 Journal article – refereed)

Optimizing sampling strategies for NMR-based metabolomics of human feces: pooled vs. unpooled analyses (2017)
Analytical Methods
Lamichhane S, Sundekilde UK, Blaedel T, Dalsgaard TK, Larsen LH, Dragsted LO, Astrup A, Bertram HC
(
A1 Journal article – refereed)

Gut microbial activity as influenced by fiber digestion: dynamic metabolomics in an in vitro colon simulator (2016)
Metabolomics
Lamichhane S, Westerhuis JA, Ouwehand AC, Saarinen MT, Forssten SD, Jensen HM, Young JF, Bertram HC, Yde CC
(
A1 Journal article – refereed)

Impact of Freezing Delay Time on Tissue Samples for Metabolomic Studies (2016)
Frontiers in Oncology
Haukaas TH, Moestue SA, Vettukattil R, Sitter B, Lamichhane S, Segura R, Giskeodegard GF, Bathen TF
(
A1 Journal article – refereed)

Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes (2016)
Cancer and Metabolism
Haukaas TH, Euceda LR, Giskeodegard GF, Lamichhane S, Krohn M, Jernstrom S, Aure MR, Lingjaerde OC, Schlichting E, Garred O, Due EU, Mills GB, Sahlberg KK, Borresen-Dale AL, Bathen TF
(
A1 Journal article – refereed)

High-resolution magic angle spinning studies of semi-hard Danbo (30+) cheese - impact of processing condition and relation to sensory perception (2015)
Special Publication- Royal Society of Chemistry
Magnetic Resonance in Food Science: Defining Food by Magnetic Resonance Lamichhane S, Yde CC, Mielby LH, Kidmose U, Moller JR, Hammershoj M, Bertram HC
(
B2 Book chapter)

Strategy for Nuclear-Magnetic-Resonance-Based Metabolomics of Human Feces (2015)
Analytical Chemistry
Lamichhane S, Yde CC, Schmedes MS, Jensen HM, Meier S, Bertram HC
(
A1 Journal article – refereed)

Impact of Dietary Polydextrose Fiber on the Human Gut Metabolome (2014)
Journal of Agricultural and Food Chemistry
Lamichhane S, Yde CC, Forssten S, Ouwehand AC, Saarinen M, Jensen HM, Gibson GR, Rastall R, Fava F, Bertram HC
(
A1 Journal article – refereed)

Metabolic characterization of triple negative breast cancer (2014)
BMC Cancer
Cao MD, Lamichhane S, Lundgren S, Bofin A, Fjosne H, Giskeodegard GF, Bathen TF
(
A1 Journal article – refereed)

Impact of pre-analytical sample handling on metabolomic studies (2013)
European Journal of Cancer
Vettukattil R, Lamichhane S, Haukaas TH, Moestue SA, Bathen TF
(
A1 Journal article – refereed)


Last updated on 2018-29-11 at 10:16