PhD Tapio Lönnberg - UTU Research Portal

Tapio Lönnberg
PhD

InFLAMES Flagship, research (InFLAMES Flagship)
Senior Research Fellow, Turku Bioscience Centre (Turku Bioscience Centre)
Docent, Biotekniikka (Bioteknologian laitos)

Turku Bioscience Centre

taplon@utu.fi

+358 29 450 3738

Tykistökatu 6

Turku

ORCID identifier: https://orcid.org/orcid.org/0000-0003-4484-5657

Lab website

Areas of expertise

Single-cell genomics, immunology

Biography

Phd 2012, University of Turku, supervised by Prof. Riitta Lahesmaa and Prof. Matej Orešič
Postdoc 2023-2016, Teichmann lab, EMBL-EBI and Wellcome Trust Sanger Institute, UK
Academy of Finland postdoc 2017-2020, Turku Bioscience Centre, University of Turku
2021- Group Leader at InFLAMES Flagship
Secretary of the Finnish Society for Immunology

Research

Our research aims at gaining deeper understanding of cell fate decisions in the immune system. We leverage single-cell and spatial omics to explore phenotypic heterogeneity beyond the immune cell subsets defined by the expression of cell surface markers. Our current research encompasses arthritic, autoimmune and cardiovascular diseases, aiming to identify core gene modules that are associated with disease state and can be exploited for more efficient diagnosis, patient stratification, and therapies.

Teaching

Modern biotechnologies and bioinformatics
Medical biotechnology
Advanced Immunology

Publications

1 of 2

Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis (2024)
- Molecular Medicine
Bhattacharya Dipabarna, Theodoropoulos Jason, Nurmi Katariina, Juutilainen Timo, Eklund Kari K., Koivuniemi Riitta, Kelkka Tiina, Mustjoki Satu, Lönnberg Tapio
(Refereed journal article or data article (A1))
Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures (2023)
- American Journal of Human Genetics
Örd Tiit, Lönnberg Tapio, Nurminen Valtteri, Ravindran Aarthi, Niskanen Henri, Kiema Miika, Õunap Kadri, Maria Maleeha, Moreau Pierre R, Mishra Pashupati P, Palani Senthil, Virta Jenni, Liljenbäck Heidi, Aavik Einari, Roivainen Anne, Ylä-Herttuala Seppo, Laakkonen Johanna P, Lehtimäki Terho, Kaikkonen Minna U
(Refereed journal article or data article (A1))
PIM kinases regulate early human Th17 cell differentiation (2023)
- Cell Reports
Buchacher Tanja, Shetty Ankitha, Koskela Saara A., Smolander Johannes, Kaukonen Riina, Sousa Antonio G. G., Junttila Sini, Laiho Asta, Rundquist Olof, Lonnberg Tapio, Marson Alexander, Rasool Omid, L. Laura, Lahesmaa Riitta
(Refereed journal article or data article (A1))
Single-cell characterization of anti-LAG-3 and anti-PD-1 combination treatment in patients with melanoma (2023)
- Journal of Clinical Investigation
Huuhtanen Jani, Kasanen Henna, Peltola Katriina, Lönnberg Tapio, Glumoff Virpi, Brück Oscar, Dufva Olli, Peltonen Karita, Vikkula Johanna, Jokinen Emmi, Ilander Mette, Lee Moon Hee, Mäkelä Siru, Nyakas Marta, Li Bin, Hernberg Micaela, Bono Petri, Lähdesmäki Harri, Kreutzman Anna, Mustjoki Satu
(Refereed journal article or data article (A1))
Transinteractome analysis reveals distinct niche requirements for isotype-based plasma cell subsets in the bone marrow (2023)
- European Journal of Immunology
Bonaud Amélie, Larraufie Pierre, Khamyath Mélanie, Szachnowski Ugo, Flint Shaun M., Brunel-Meunier Nadège, Delhommeau François, Munier Annie, Lönnberg Tapio, Toffano-Nioche Claire, Gautheret Daniel, Balabanian Karl, Espéli Marion
(Refereed journal article or data article (A1))
Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia (2022)
- Reproduction
Rytkönen Kalle T, Adossa Nigatu, Mahmoudian Mehrad, Lönnberg Tapio, Poutanen Matti, Elo Laura L
(Refereed journal article or data article (A1))
Evolution and modulation of antigen-specific T cell responses in melanoma patients (2022)
- Nature Communications
Huuhtanen Jani, Chen Liang, Jokinen Emmi, Kasanen Henna, Lönnberg Tapio, Kreutzman Anna, Peltola Katriina, Hernberg Micaela, Wang Chunlin, Yee Cassian, Lähdesmäki Harri, Davis Mark M, Mustjoki Satu
(Refereed journal article or data article (A1))
Single-cell characterization of dog allergen–specific T cells reveals TH2 heterogeneity in allergic individuals (2022)
- Journal of Allergy and Clinical Immunology
Vandamme Celine, Rytkönen-Nissinen Marja, Lönnberg Tapio, Randell Jukka, Harvima Rauno J., Kinnunen Tuure, Virtanen Tuomas
(Refereed journal article or data article (A1))
Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia (2022)
- Nature Communications
Huuhtanen Jani, Bhattacharya Dipabarna, Lönnberg Tapio, Kankainen Matti, Kerr Cassandra, Theodoropoulos Jason, Rajala Hanna, Gurnari Carmelo, Kasanen Tiina, Braun Till, Teramo Antonella, Zambello Renato, Herling Marco, Ishida Fumihiro, Kawakami Toru, Salmi Marko, Loughran Thomas, Maciejewski Jaroslaw P., Lähdesmäki Harri, Kelkka Tiina, Mustjoki Satu
(Refereed journal article or data article (A1))
Human adipose tissue-derived stem cell paracrine networks vary according metabolic risk and after TNFα-induced death: an analysis at the single-cell level (2021)
- Metabolism
Oliva-Olivera Wilfredo, Castellano-Castillo Daniel, von Meyenn Ferdinand, Cardona Fernando, Lönnberg Tapio, Tinahones Francisco J
(Refereed journal article or data article (A1))
Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci (2021)
- Circulation Research
Ord Tiit, Ounap Kadri, Stolze Lindsey K., Aherrahrou Redouane, Nurminen Valtteri, Toropainen Anu, Selvarajan Ilakya, Lönnberg Tapio, Aavik Einari, Ylä-Herttuala Seppo, Civelek Mete, Romanoski Casey E., Kaikkonen Minna U.
(Refereed journal article or data article (A1))
Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial (2021)
- Clinical Cancer Research
Virtakoivu Reetta, Rannikko Jenna H, Viitala Miro, Vaura Felix, Takeda Akira, Lönnberg Tapio, Koivunen Jussi, Jaakkola Panu, Pasanen Annika, Shetty Shishir, de Jonge Maja JA, Robbrecht Debbie, Ma Yuk Ting, Skyttä Tanja, Minchom Anna, Jalkanen Sirpa, Karvonen Matti K, Mandelin Jami, Bono Petri, Hollmén Maija
(Refereed journal article or data article (A1))
Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+T Lymphocyte Signature (2020)
- Frontiers in Immunology
Tiina Kelkka, Paula Savola, Dipabarna Bhattacharya, Jani Huuhtanen, Tapio Lönnberg, Matti Kankainen, Kirsi Paalanen, Mikko Tyster, Maija Lepistö, Pekka Ellonen, Johannes Smolander, Samuli Eldfors, Bhagwan Yadav, Sofia Khan, Riitta Koivuniemi, Christopher Sjöwall, Laura L. Elo, Harri Lähdesmäki, Yuka Maeda, Hiroyoshi Nishikawa, Marjatta Leirisalo-Repo, Tuulikki Sokka-Isler, Satu Mustjoki
(Refereed journal article or data article (A1))
Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics (2020)
- Circulation Research
Marie A.C. Depuydt, Koen H.M. Prange, Lotte Slenders, Tiit Örd, Danny Elbersen, Arjan Boltjes, Saskia C.A. de Jager, Folkert W. Asselbergs, Gert J. de Borst, Einari Aavik, Tapio Lönnberg, Esther Lutgens, Christopher K. Glass, Hester M. den Ruijter, Minna U. Kaikkonen, Ilze Bot, Bram Slütter, Sander W. van der Laan, Seppo Yla-Herttuala, Michal Mokry, Johan Kuiper, Menno P.J. de Winther, Gerard Pasterkamp
(Refereed journal article or data article (A1))
Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities (2020)
- Genome Medicine
Juha Mehtonen, Susanna Teppo, Mari Lahnalampi, Aleksi Kokko, Riina Kaukonen, Laura Oksa, Maria Bouvy-Liivrand, Alena Malyukova, Artturi Mäkinen, Saara Laukkanen, Petri I. Mäkinen, Samuli Rounioja, Pekka Ruusuvuori, Olle Sangfelt, Riikka Lund, Tapio Lönnberg, Olli Lohi, Merja Heinäniemi
(Refereed journal article or data article (A1))
Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease (2020)
- Nature Communications
Daehong Kim, Giljun Park, Jani Huuhtanen, Sofie Lundgren, Rajiv K. Khajuria, Ana M. Hurtado, Cecilia Muñoz-Calleja, Laura Cardeñoso, Valle Gómez-García de Soria, Tzu Hua Chen-Liang, Samuli Eldfors, Pekka Ellonen, Sari Hannula, Matti Kankainen, Oscar Bruck, Anna Kreutzman, Urpu Salmenniemi, Tapio Lönnberg, Andrés Jerez, Maija Itälä-Remes, Mikko Myllymäki, Mikko A. I. Keränen, Satu Mustjoki
(Refereed journal article or data article (A1))
The Conjugation of Antibodies for the Simultaneous Detection of Surface Proteins and Transcriptome Analysis at a Single-Cell Level (2020) Immunometabolism: Methods and protocols Iivari Kleino, Eliisa Kekäläinen, Tapio Lönnberg
(Refereed article in compilation book (A3))
Transcriptome dynamics of CD4(+) T cells during malaria maps gradual transit from effector to memory (2020)
- Nature Immunology
Megan S. F. Soon, Hyun Jae Lee, Jessica A. Engel, Jasmin Straube, Bryce S. Thomas, Clara P. S. Pernold, Lachlan S. Clarke, Pawat Laohamonthonkul, Rohit N. Haldar, Cameron G. Williams, Lianne I. M. Lansink, Marcela L. Moreira, Michael Bramhall, Lambros T. Koufariotis, Scott Wood, Xi Chen, Kylie R. James, Tapio Lönnberg, Steven W. Lane, Gabrielle T. Belz, Christian R. Engwerda, David S. Khoury, Miles P. Davenport, Valentine Svensson, Sarah A. Teichmann, Ashraful Haque
(Refereed journal article or data article (A1))
Early Detection of Peripheral Blood Cell Signature in Children Developing Beta-Cell Autoimmunity at a Young Age (2019)
- Diabetes
Henna Kallionpää, Juhi Somani, Soile Tuomela, Ubaid Ullah, Rafael de Albuquerque, Tapio Lönnberg, Elina Komsi, Heli Siljander, Jarno Honkanen, Taina Härkönen, Aleksandr Peet, Vallo Tillmann, Vikash Chandra, Mahesh Kumar Anagandula, Gun Frisk, Timo Otonkoski, Omid Rasool, Riikka Lund, Harri Lähdesmäki, Mikael Knip, Riitta Lahesmaa
(Refereed journal article or data article (A1))
Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease (2019)
- Clinical Epigenetics
Konki Mikko, Malonzo Maja, Karlsson Ida K, Lindgren Noora, Ghimire Bishwa, Smolander Johannes, Scheinin Noora M, Ollikainen Miina, Laiho Asta, Elo Laura L, Lönnberg Tapio, Röyttä Matias, Pedersen Nancy L, Kaprio Jaakko, Lähdesmäki Harri, Rinne Juha O, Lund Riikka J
(Refereed journal article or data article (A1))