Sisko Tauriainen
PhD, Adjunct professor

University Lecturer, Institute of Biomedicine (Institute of Biomedicine)

sisko.tauriainen@utu.fi
+358 29 450 4554
+358 46 921 4201






Areas of expertise
Virology; Parechoviruses; Enteroviruses; Cell cultures

Biography

MSc, PhD in Biochemistry
Adjunct professor in Molecular biology/Molecular virology

Current position: University lecturer
Former positions: university teacher at University of Turku; senior researcher and earlier post-doctoral researcher at University of Tampere; post-doctoral researcher at Wayne State University, Detroit, Michigan; Doctoral student at University of Turku, department of Biochemistry

Major funding: Academy of Finland, Jane and Aatos Erkko Foundation

Student supervision: 4 PhD and over 20 undergraduate theses

Publications: over 40 refereed original research articles, 7 review articles or conference proceedings



Research

Human parechoviruses (HPeVs) belong to the Picornavirdae family. They are small, non-enveloped and have a positive strand RNA genome of about 7300 bases. HPeV type 1 is a common virus infecting mainly children; practically everyone contacts it by the age of 3 years. HPeVs cause usually mild respiratory and gastrointestinal symptoms, but also severe central nervous systems infections, like meningitis, encephalitis and sepsis-like disease, have been detected in new-born babies. Mainly these severe symptoms are caused by HPeV3.
We have studied the HPeV epidemiology and disease connections and confirmed that HPeVs are common and the severe diseases do occur also in Finland. We were the first to identify HPeV4 as a serious disease causing type of these viruses in children with sepsis-like disease. Our studies focus on the disease causing abilities of these viruses and why the causative type is mostly HPeV3. The studies are done in human neuronal cell models, in vitro. The virus-cell interactions are studied and how the changes in virus genome affect virus infectivity, speed of virus replication as well as cellular metabolism and morphology.



Teaching
  1. Lectures: Enteric viruses, Virus life cycle, Picornaviruses
  2. Tutoring (Case Based Learning): Water and food borne viruses
  3. Lab courses: Microbial diagnostics


Publications
Go to first page Go to previous page 1 of 2 Go to next page Go to last page

No Association Between Ljungan Virus Seropositivity and the Beta-Cell Damaging Process in the Finnish Type 1 Diabetes Prediction and Prevention Study Cohort (2019)
Pediatric Infectious Disease Journal
Jääskeläinen AJ, Nurminen N, Kolehmainen P, Smura T, Tauriainen S, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H, Vapalahti O, Kallio-Kokko H
(
A1 Journal article – refereed)

Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity (2017)
Diabetologia
Honkanen H, Oikarinen S, Nurminen N, Laitinen OH, Huhtala H, Lehtonen J, Ruokoranta T, Hankaniemi MM, Lecouturier V, Almond JW, Tauriainen S, Simell O, Ilonen J, Veijola R, Viskari H, Knip M, Hyoty H, Hyoty H
(
A1 Journal article – refereed)

Intertypic recombination of human parechovirus 4 isolated from infants with sepsis-like disease (2017)
Journal of Clinical Virology
Kolehmainen P, Siponen A, Smura T, Kallio-Kokko H, Vapalahti O, Jaaskelainen A, Tauriainen S
(
A1 Journal article – refereed)

Human Parechovirus 1 Infection Occurs via alpha V beta 1 Integrin (2016)
PLoS ONE
Merilahti P, Tauriainen S, Susi P
(
A1 Journal article – refereed)

Human parechovirus type 3 and 4 associated with severe infections in young children (2014)
Pediatric Infectious Disease Journal
Kolehmainen P, Jääskeläinen A, Blomqvist S, Kallio-Kokko H, Nuolivirta K, Helminen M, Roivainen M, Lappalainen M, Tauriainen S
(
A1 Journal article – refereed)

Immunological changes and increased expression of myxovirus resistance protein a in thyroid tissue of patients with recent onset and untreated Graves' disease (2014)
Thyroid
Hammerstad SS, Jahnsen FL, Tauriainen S, Hyöty H, Paulsen T, Norheim I, Dahl-Jørgensen K.
(
A1 Journal article – refereed)

Virus antibody survey in different European populations indicates risk association between coxsackievirus B1 and type 1 diabetes (2014)
Diabetes
Oikarinen S, Tauriainen S, Hober D, Lucas B, Vazeou A, Sioofy-Khojine A, Bozas E, Muir P, Honkanen H, Ilonen J, Knip M, Keskinen P, Saha MT, Huhtala H, Stanway G, Bartsocas C, Ludvigsson J, Taylor K, Hyöty H; VirDiab Study Group
(
A1 Journal article – refereed)

Detection of enterovirus in the thyroid tissue of patients with graves' disease (2013)
Journal of Medical Virology
Hammerstad SS, Tauriainen S, Hyoty H, Paulsen T, Norheim I, Dahl-Jorgensen K
(
A1 Journal article – refereed)

Enterovirus infections in early childhood and the risk of atopic disease – a nested case-control study (2013)
Clinical and Experimental Allergy
Korhonen L, Kondrashova A, Tauriainen S, Haapala AM, Huhtala H, Ilonen J, Simell O, Knip M, Lönnrot M, Hyöty H
(
A1 Journal article – refereed)

Evidence of Ljungan Virus Specific Antibodies in Humans and Rodents, Finland (2013)
Journal of Medical Virology
Jääskeläinen AJ, Kolehmainen P, Voutilainen L, Hauffe HC, Kallio-Kokko H, Lappalainen M, Tolf C, Lindberg AM, Henttonen H, Vaheri A, Tauriainen S, Vapalahti O
(
A1 Journal article – refereed)

First two cases of neonatal human parechovirus 4 infection with manifestation of suspected sepsis, Finland (2013)
Journal of Clinical Virology
Jaaskelainen AJ, Kolehmainen P, Kallio-Kokko H, Nieminen T, Koskiniemi M, Tauriainen S, Lappalainen M
(
A1 Journal article – refereed)

Human enterovirus 71 strains in the background population and in hospital patients in Finland (2013)
Journal of Clinical Virology
Honkanen H, Oikarinen S, Pakkanen O, Ruokoranta T, Pulkki M, Laitinen O, Tauriainen S, Korpela S, Lappalainen M, Vuorinen T, Haapala A, Veijola R, Simell O, Ilonen J, Knip M, Hyöty H
(
A1 Journal article – refereed)

Human parechovirus and the risk of type 1 diabetes (2013)
Journal of Medical Virology
Kolehmainen P, Koskiniemi M, Oikarinen S, Veijola R, Simell O, Ilonen J, Knip M, Hyöty H, Tauriainen S
(
A1 Journal article – refereed)

Human parechovirus seroprevalence in Finland and the Netherlands (2013)
Journal of Clinical Virology
Westerhuis B, Kolehmainen P, Benschop K, Nurminen N, Koen G, Koskiniemi M, Simell O, Knip M, Hyoty H, Wolthers K, Tauriainen S
(
A1 Journal article – refereed)

Inflammation and Increased Myxovirus Resistance Protein A Expression in Thyroid Tissue in the Early Stages of Hashimoto's Thyroiditis (2013)
Thyroid
Hammerstad SS, Jahnsen FL, Tauriainen S, Hyoty H, Paulsen T, Norheim I, Dahl-Jorgensen K
(
A1 Journal article – refereed)

Is alcoholic pancreatitis associated with enteroviral infection? (2013)
World Journal of Gastroenterology
Khan J, Nordback I, Seppanen H, Lappalainen-Lehto R, Jarvinen S, Oikarinen S, Tauriainen S, Raty S, Hyoty H, Sand J
(
A1 Journal article – refereed)

Human parechoviruses are frequently detected in stool of healthy Finnish children (2012)
Journal of Clinical Virology
Kolehmainen P, Oikarinen S, Koskiniemi M, Simell O, Ilonen J, Knip M, Hyoty H, Tauriainen S
(
A1 Journal article – refereed)

Interaction of enterovirus infection and cow's milk-based formula nutrition in type 1 diabetes-associated autoimmunity (2012)
Diabetes/Metabolism Research and Reviews
Lempainen J, Tauriainen S, Vaarala O, Makela M, Honkanen H, Marttila J, Veijola R, Simell O, Hyoty H, Knip M, Ilonen J
(
A1 Journal article – refereed)

Maternal Enterovirus Infection as a Risk Factor for Type 1 Diabetes in the Exposed Offspring (2012)
Diabetes Care
Viskari Hanna, Knip Mikael, Tauriainen Sisko, Huhtala Heini, Veijola Riitta, Ilonen Jorma, Simell Olli, Surcel Heljä-Marja, Hyöty Heikki
(
A1 Journal article – refereed)

Role of enterovirus infections in IgE sensitization (2012)
Journal of Medical Virology
Seiskari T, Kondrashova A, Tauriainen S, Knip M, Viskari H, Haapala AM, Hyoty H
(
A1 Journal article – refereed)


Last updated on 2019-20-09 at 02:20