Johanna Lempainen
Clinical lecturer
johanna.lempainen@utu.fi Department of Pediatrics, Institute of Clinical Medicine, University of Turku Unit for Rare Diseases, Turku University Hospital |
Areas of expertise
pediatrics; pathogenesis of type 1 diabetes; pediatric infections; pediatric immunology
pediatrics; pathogenesis of type 1 diabetes; pediatric infections; pediatric immunology
Biography
Docent Johanna Lempainen
graduated from medical school in 2004 (University of Turku) and defended her
PhD theses on pathogenesis of type 1 diabetes in 2009. She received specialist
licence in paediatrics in 2015 and was appointed as a docent of experimental
paediatrics in 2018 (University of Turku). She is currently working as clinical
lecturer at the department of pediatrics at University of Turku and as
specialist at the Unit for Rare Diseases, Turku University Hospital. She
participates in neonatal screening for severe immunodeficiencies and in
laboratory diagnostics of immunodeficiencies. Training for subspecialty in
pediatric infections and immunodeficiencies is ongoing.
Docent Johanna Lempainen
graduated from medical school in 2004 (University of Turku) and defended her
PhD theses on pathogenesis of type 1 diabetes in 2009. She received specialist
licence in paediatrics in 2015 and was appointed as a docent of experimental
paediatrics in 2018 (University of Turku). She is currently working as clinical
lecturer at the department of pediatrics at University of Turku and as
specialist at the Unit for Rare Diseases, Turku University Hospital. She
participates in neonatal screening for severe immunodeficiencies and in
laboratory diagnostics of immunodeficiencies. Training for subspecialty in
pediatric infections and immunodeficiencies is ongoing.
Research
Docent Lempainen’s
thesis in 2009 focused on the pathogenesis of type 1 diabetes. Since then her
research work has further focused on the heterogeneity of type 1 diabetes
pathogenesis. In 2011 she worked as visiting researcher in the
BabyDiab-diabetes study group in Munich,
Germany. Her current research interests comprise the etiology of beta-cell
autoimmunity in respect of immunological, genetic and epigenetic factors and
disturbances in early microbial contacts and are a part of the prospective
Diabetes Prediction and Prevention (DIPP) study. In addition, she participates
in research projects aiming at early detection of bacterial and viral
infections in infants and children in order to avoid unnecessary antibiotic
exposure. Since January 2020 docent Lempainen is the principal investigator of the Immunogenetics laboratory and PI and member of steering committee in the DIPP study at the University of Turku.
Docent Lempainen’s
thesis in 2009 focused on the pathogenesis of type 1 diabetes. Since then her
research work has further focused on the heterogeneity of type 1 diabetes
pathogenesis. In 2011 she worked as visiting researcher in the
BabyDiab-diabetes study group in Munich,
Germany. Her current research interests comprise the etiology of beta-cell
autoimmunity in respect of immunological, genetic and epigenetic factors and
disturbances in early microbial contacts and are a part of the prospective
Diabetes Prediction and Prevention (DIPP) study. In addition, she participates
in research projects aiming at early detection of bacterial and viral
infections in infants and children in order to avoid unnecessary antibiotic
exposure. Since January 2020 docent Lempainen is the principal investigator of the Immunogenetics laboratory and PI and member of steering committee in the DIPP study at the University of Turku.
Teaching
Docent Lempainen works
as clinical lecturer in pediatrics (part-time) since January 2017.
Docent Lempainen works
as clinical lecturer in pediatrics (part-time) since January 2017.
Publications
- Increased Frequency of the HLA-DRB1*04:04-DQA1*03-DQB1*03:02 Haplotype Among HLA-DQB1*06:02-Positive Children With Type 1 Diabetes (2024)
- Diabetes
(Refereed journal article or data article (A1)) - Borrelioosi (2023) Lastentaudit Saxen Harri, Lempainen Johanna
(Article in a professional research book (D2)) - Childhood manifestations of 22q11.2 deletion syndrome: A Finnish nationwide register-based cohort study (2023)
- Acta Paediatrica
(Refereed journal article or data article (A1)) - Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children (2023)
- Frontiers in Endocrinology
(Refereed journal article or data article (A1)) - Coronavirus spike protein-specific antibodies indicate frequent infections and reinfections in infancy and among BNT162b2-vaccinated healthcare workers (2023)
- Scientific Reports
(Refereed journal article or data article (A1)) - CXADR polymorphism rs6517774 modifies islet autoimmunity characteristics and exhibits sex disparity (2023)
- Frontiers in Genetics
(Refereed journal article or data article (A1)) - DNA methylation differences within INS, PTPN22 and IL2RA promoters in lymphocyte subsets in children with type 1 diabetes and controls (2023)
- Autoimmunity
(Refereed journal article or data article (A1)) - ERN-verkostot kokoavat harvinaissairauksien osaajat yhteen (2023)
- Lääkärilehti
(Refereed review article in scientific journal (A2)) - Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes (2023)
- Diabetes Research and Clinical Practice
(Refereed journal article or data article (A1)) - HLA-DQ-conferred risk for type 1 diabetes does not alter neutralizing antibody response to a widely used enterovirus vaccine, the poliovirus vaccine (2023)
- Journal of Medical Virology
(Refereed journal article or data article (A1)) - Persistent T cell-mediated immune responses against Omicron variants after the third COVID-19 mRNA vaccine dose (2023)
- Frontiers in Immunology
(Refereed journal article or data article (A1)) - SARS-CoV-2 and type 1 diabetes in children in Finland: an observational study (2023)
- Lancet Diabetes and Endocrinology
(Refereed journal article or data article (A1)) - T cell immunity following COVID-19 vaccination in adult patients with primary antibody deficiency - a 22-month follow-up (2023)
- Frontiers in Immunology
(Refereed journal article or data article (A1)) - Associations between deduced first islet specific autoantibody with sex, age at diagnosis and genetic risk factors in young children with type 1 diabetes (2022)
- Pediatric Diabetes
(Refereed journal article or data article (A1)) - Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants (2022)
- Nature Communications
(Refereed journal article or data article (A1)) - Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage (2022)
- Diabetologia
(Refereed journal article or data article (A1)) - Heterogeneity in the presentation of clinical type 1 diabetes defined by the level of risk conferred by human leukocyte antigen class II genotypes (2022)
- Pediatric Diabetes
(Refereed journal article or data article (A1)) - Influenza and respiratory syncytial virus during the COVID-19 pandemic: Time for a new paradigm? (2022)
- Pediatric Pulmonology
(Article or data-article in scientific journal (B1)) - Long-Lasting T Cell Responses in BNT162b2 COVID-19 mRNA Vaccinees and COVID-19 Convalescent Patients (2022)
- Frontiers in Immunology
(Refereed journal article or data article (A1)) - Low pre-vaccination SARS-CoV-2 seroprevalence in Finnish health care workers: a prospective cohort study (2022)
- Infectious Diseases
(Refereed journal article or data article (A1))