Kumail Motiani
MD

PET Basic Operations (Turku PET Centre)

kukumo@utu.fi







Research
The benefits of exercise in the treatment of diabetes have been advocated since as early as the 5th century. Most of the consensus is because exercise improves insulin sensitivity (mostly through its effects in the muscle). But just as the aetiology of diabetes is multifactorial, the beneficial effects of exercise cannot be attributed just to the changes in the muscle. Other organs (liver, pancreas and intestine) have been shown to also play an important role in the pathogenesis. Although much has been debated about the role of these organs in the pathogenesis of type 2 diabetes little attention has been directed towards how exercise affects these organs.
I am particularly interested in understanding how the exercise-mediated signals affect these organs and how these interactions lead to improvements in the whole body metabolism. My research aims to answer these questions and it will be one of the first where the effects of exercise will be studied so extensively in humans and animals using modern molecular imaging techniques available. Furthermore, by measuring how liver, pancreas and intestine respond to different modes of exercise intensities in healthy and type 2 diabetic patients will provide new details for innovative interventions aimed at preventing diabetes and complications associated with it.


Publications

Comment on ‘Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial’. Reply to Amini P and Moharamzadeh S [letter] (2019)
Diabetologia
Marja A Heiskanen, Kumail K Motiani, Andrea Mari, Jari-Joonas Eskelinen, Kirsi A Virtanen, Eliisa Löyttyniemi, Kari K Kalliokoski, Jarna C Hannukainen
(
B1 Journal article)

Effects of short-term exercise training on liver, pancreas and intestinal metabolism (2019) Motiani Kumail Kumar
(
G5 Doctoral dissertation (article))

Exercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia (2019)
Medicine and Science in Sports and Exercise
Motiani Kumail Kumar, Collado Maria Carmen, Eskelinen Jari-Joonas, Virtanen Kirsi A, Löyttyniemi Eliisa, Salminen Seppo, Nuutila Pirjo, Kalliokoski Kari K, Hannukainen Jarna C
(
A1 Journal article – refereed)

Career pathways and professional skills of postgraduate students from a dental research-intensive programme (2018)
European Journal of Dental Education
Kumari Amrita, Wu David T., Motiani Kumail K., Wu Kevin Y., Palumbo Maria, Tran Simon D.
(
A1 Journal article – refereed)

Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial (2018)
Diabetologia
Marja A. Heiskanen, Kumail K. Motiani, Andrea Mari, Virva Saunavaara, Jari-Joonas Eskelinen, Kirsi A. Virtanen, Mikko Koivumäki, Eliisa Löyttyniemi, Pirjo Nuutila, Kari K. Kalliokoski, Jarna C. Hannukainen
(
A1 Journal article – refereed)

Increased insulin-stimulated glucose uptake in both leg and arm muscles after sprint interval and moderate intensity training in subjects with Type 2 Diabetes or Prediabetes (2018)
Scandinavian Journal of Medicine and Science in Sports
T. J. Sjöros, M. A. Heiskanen, K. K. Motiani, E. Löyttyniemi, J-J. Eskelinen, K. A. Virtanen, N. J. Savisto, O. Solin, J. C. Hannukainen, K. K. Kalliokoski
(
A1 Journal article – refereed)

Short-term interval training alters brain glucose metabolism in subjects with insulin resistance (2018)
Journal of Cerebral Blood Flow and Metabolism
Sanna M Honkala, Jarkko Johansson, Kumail K Motiani, Jari-Joonas Eskelinen, Kirsi A Virtanen, Eliisa Löyttyniemi, Juhani Knuuti, Pirjo Nuutila, Kari K Kalliokoski, Jarna C Hannukainen
(
A1 Journal article – refereed)

Decreased insulin-stimulated brown adipose tissue glucose uptake after short-term exercise training in healthy middle-aged men (2017)
Diabetes, Obesity and Metabolism
Motiani P, Virtanen KA, Motiani KK, Eskelinen JJ, Middelbeek RJ, Goodyear LJ, Savolainen AM, Kemppainen J, Jensen J, Din MU, Saunavaara V, Parkkola R, Loyttyniemi E, Knuuti J, Nuutila P, Kalliokoski KK, Hannukainen JC, Hannukainen JC
(
A1 Journal article – refereed)

Effects of short-term exercise training on intestinal metabolism and gut microbiota in subjects with insulin resistance (2017)
Diabetologia
K.K. Motiani, M.C. Collado, J.-J. Eskelinen, K.A. Virtanen, E. Löyttyniemi, S. Salminen , P. Nuutila, K.K. Kalliokoski, J.C. Hannukainen
(
O2 Other)

Exercise Training Reduces Intrathoracic Fat Regardless of Defective Glucose Tolerance (2017)
Medicine and Science in Sports and Exercise
Sanna M. Honkala, Kumail K. Motiani, Jari-Joonas Eskelinen, Anna Savolainen, Virva Saunavaara, Kirsi A. Virtanen, Eliisa Löyttyniemi, Jukka Kapanen, Juhani Knuuti, Kari K. Kalliokoski, Jarna C. Hannukainen
(
A1 Journal article – refereed)

Sprint interval training decreases left-ventricular glucose uptake compared to moderate-intensity continuous training in subjects with type 2 diabetes or prediabetes (2017)
Scientific Reports
Heiskanen MA, Sjoros TJ, Heinonen IHA, Loyttyniemi E, Koivumaki M, Motiani KK, Eskelinen JJ, Virtanen KA, Knuuti J, Hannukainen JC, Kalliokoski KK
(
A1 Journal article – refereed)

Two weeks of exercise training improves bone marrow metabolism (2017)
Diabetologia
R.A. Ojala, K.K. Motiani, J.J. Eskelinen, E. Löyttyniemi, P. Nuutila, K.K. Kalliokoski, J.C. Hannukainen
(
O2 Other)

Two weeks of moderate-intensity continuous training, but not high-intensity interval training, increases insulin-stimulated intestinal glucose uptake (2017)
Journal of Applied Physiology
Motiani KK, Savolainen AM, Eskelinen JJ, Toivanen J, Ishizu T, Yli-Karjanmaa M, Virtanen KA, Parkkola R, Kapanen J, Gronroos TJ, Haaparanta-Solin M, Solin O, Savisto N, Ahotupa M, Löyttyniemi E, Knuuti J, Nuutila P, Kalliokoski KK, Hannukainen JC
(
A1 Journal article – refereed)

Exercise Training Reduces Epi- and Pericardial Fat Masses in Healthy and Type 2 Diabetic Subjects (2016)
Diabetes
Honkala SM, Motiani KK, Eskelinen JJ, Savolainen AM, Saunavaara V, Virtanen KA, Loyttyniemi E, Knuuti J, Kalliokoski K, Hannukainen JC
(
O2 Other)

High-intensity interval training changes insulin stimulated cerebral glucose uptake of in subjects with impaired glucose tolerance (2016)
Diabetologia
Honkala SM, Johansson J, Motiani KK, Eskelinen JJ, Virtanen KA, Loyttyniemi E, Nuutila P, Knuuti J, Kalliokoski KK, Hannukainen JC
(
O2 Other)

Left-ventricular vascular and metabolic adaptations to high-intensity interval and moderate intensity continuous training: A randomized trial in healthy middle-aged men (2016)
Journal of Physiology
Jari-Joonas Eskelinen, Ilkka Heinonen, Eliisa Löyttyniemi, Juuso Hakala, Marja A. Heiskanen, Kumail K. Motiani, Kirsi Virtanen, Jussi P. Pärkkä, Juhani Knuuti, Jarna C. Hannukainen, Kari K. Kalliokoski
(
A1 Journal article – refereed)

Moderate intensity exercise training rapidly increases insulin stimulated intestinal glucose uptake in sedentary individuals (2015)
Diabetologia
Motiani KK, Savolainen A, Eskelinen J, Virtanen KA, Parkkola R, Knuuti J, Nuutila P, Kalliokoski KK, Hannukainen JC
(
O2 Other)


Last updated on 2019-01-08 at 02:20