Olli Tenovuo
MD, PhD, Prof. of Neurotraumatology
Department of Neurosciences ollten@utu.fi ORCID identifier: https://orcid.org/0000-0003-1876-3180 |
traumatic brain injury; rehabilitation; biomarkers; imaging
I have a long and profound experience in the field of traumatic brain injuries (TBIs), both clinically and scientifically. Patients with TBI of different severities have been my main clinical interest since early 1990’s, and during the years I have treated about 6 000 patients with TBI. Since 1996 I have led a multidisciplinary research group on TBIs, which has expanded steadily. Currently our group includes > 40 researchers, 21 of which are PhD students and 7 are post docs. They represent widely different disciplines, such as neurosurgery, neurology, neuroanaesthesiology, neuroradiology, neuropsychology, clinical neurophysiology, psychiatry etc. I have conducted also large international research projects and am currently in a leading position in several trials. I have also experience on RCTs on the field. My group has a wide collaborative network both nationally and internationally, both in experimental and clinical research. Currently we have active research collaboration with ten national and 22 international (from 13 countries) research groups.
The research of our TBI has included topics from various disciplines, from psychiatry and neuropsychology to epidemiology, neurosurgery, and biochemistry. During the recent years we have mainly focused in three areas: 1) blood-based brain injury biomarkers, 2) novel brain imaging methodologies, and 3) multifaceted approach to diagnostic and prognostic modeling of TBI. We aim at solving clinical problems and conducting research which is easily transferred to clinical practice. We also collaborate with basic science in order to reveal brain injury mechanisms, since these help in understanding clinical phenomena and in developing new interventions. International collaboration and co-work are an essential part of our research policy.
Teaching about TBI has been a major part of my work for almost 20 years, both for medical students at the Turku University as well as nationally and internationally. Annually I have about 160 hrs of teaching for medical students.
- An outlier analysis for acute blood biomarkers of moderate and severe traumatic brain injury (2024)
- Journal of Neurotrauma
(Refereed journal article or data article (A1)) - Late Blood Levels of Neurofilament Light Correlate With Outcome in Patients With Traumatic Brain Injury (2024)
- Journal of Neurotrauma
(Refereed journal article or data article (A1)) - Accuracy of Manual Intracranial Pressure Recording Compared to a Computerized High-Resolution System: A CENTER-TBI Analysis (2023)
- Neurocritical Care
(Refereed journal article or data article (A1)) - A comparison of diffusion tensor imaging tractography and constrained spherical deconvolution with automatic segmentation in traumatic brain injury (2023)
- NeuroImage: Clinical
(Refereed journal article or data article (A1)) - Association of cognitive-linguistic deficits to diffusion tensor imaging parameters in moderate to severe traumatic diffuse axonal injury (2023)
- Applied Neuropsychology Adult
(Refereed journal article or data article (A1)) - Cognitive functions and symptoms predicting later use of psychiatric services following mild traumatic brain injury in school-age (2023)
- Brain Injury
(Refereed journal article or data article (A1)) - Outcome and survival of surgically treated acute subdural hematomas and postcraniotomy hematomas–A retrospective cohort study (2023)
- Brain and Spine
(Refereed journal article or data article (A1)) - Perceived Communication Abilities after Moderate to Severe Traumatic Diffuse Axonal Injury (2023)
- Brain Injury
(Other (O2)) - Plasma neurofilament light admission levels and development of axonal pathology in mild traumatic brain injury (2023)
- BMC Neurology
(Refereed journal article or data article (A1)) - The lower limit of reactivity as a potential individualised cerebral perfusion pressure target in traumatic brain injury: a CENTER-TBI high-resolution sub-study analysis (2023)
- Critical Care
(Refereed journal article or data article (A1)) - Trajectories of Interleukin 10 and Heart Fatty Acid-Binding Protein Levels in Traumatic Brain Injury Patients with or without Extracranial Injuries (2023)
- Frontiers in Neurology
(Refereed journal article or data article (A1)) - Blood-based biomarkers and traumatic brain injury-A clinical perspective (2022)
- Acta Neurologica Scandinavica
(Refereed review article in scientific journal (A2)) - Cerebral Microbleeds and Structural White Matter Integrity in Patients With Traumatic Brain Injury-A Diffusion Tensor Imaging Study (2022)
- Frontiers in Neurology
(Refereed journal article or data article (A1)) - Cognitive-linguistic skills of adults who suffered a diffuse axonal injury in childhood or youth (2022) Raukola-Lindblom Marjaana, Ljungqvist Linda, Kurki Timo, Hämäläinen Heikki, Tenovuo Olli
(Other (O2)) - Post-acute blood biomarkers and disease progression in traumatic brain injury (2022)
- Brain
(Refereed journal article or data article (A1)) - Potential of heart fatty-acid binding protein, neurofilament light, interleukin-10 and S100 calcium-binding protein B in the acute diagnostics and severity assessment of traumatic brain injury (2022)
- Emergency Medicine Journal
(Refereed journal article or data article (A1)) - Rehabilitation and outcomes after complicated vs uncomplicated mild TBI: results from the CENTER-TBI study (2022)
- BMC Health Services Research
(Refereed journal article or data article (A1)) - Serum metabolome associated with severity of acute traumatic brain injury (2022)
- Nature Communications
(Refereed journal article or data article (A1)) - Structural Brain Connectivity Correlates with Outcome in Mild Traumatic Brain Injury (2022)
- Journal of Neurotrauma
(Refereed journal article or data article (A1)) - Traumatic brain injury: progress and challenges in prevention, clinical care, and research (2022)
- Lancet Neurology
(Refereed journal article or data article (A1))