Xiang-Guo Li
Assistant Professor
Turku PET Centre, University of Turku xiali@utu.fi Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/0000-0002-9118-7223 |
Radiochemistry, Radiopharmaceuticals, PET imaging, New drug development
I am a radiochemist and medicinal chemist working at Turku PET Centre, University of Turku, Finland. I received my PhD degree from the Institute of Biomedicine, Faculty of Medicine, University of Turku, in 2008. Then I was at a Post-doctoral position funded by the Academy of Finland during 2010-2012. I received my Docentship in 2012 from University of Turku. Since 2013, I have been working at Turku PET Centre. At present, I work as an Assistant Professor in Radiochemistry, and Principal Investigator in the InFLAMES Research Flagship.
Basic research in radiochemistry including methodological development for radiosynthesis and radiolabeling techniques. We have been able to radiolabel many types of molecules including small organic compounds, peptides, antibody and antibody fragments, oligonucleotides, oligosaccharides etc.
Development of new radiopharmaceuticals for PET imaging of inflammatory diseases and immunological diseases.
The radiolabeled molecules are for imaging diseases or for studying disease machanisms with PET.
I teach in the courses of Radiopharmaceutical Chemistry, Radiolabeling techniques, Measuring techniques in radiochemistry, PET Basics, and supervise BSc, MSc and PhD students.
- Imaging of Myocardial αvβ3Integrin Expression for Evaluation of Myocardial Injury After Acute Myocardial Infarction (2024)
- Journal of Nuclear Medicine
(Refereed journal article or data article (A1)) - Aluminum Fluoride-18 Labeled Mannosylated Dextran: Radiosynthesis and Initial Preclinical Positron Emission Tomography Studies (2023)
- Molecular Imaging and Biology
(Refereed journal article or data article (A1)) - Detection of Intestinal Inflammation by Vascular Adhesion Protein-1-Targeted [68Ga]Ga-DOTA-Siglec-9 Positron Emission Tomography in Murine Models of Inflammatory Bowel Disease (2023)
- Molecular Imaging and Biology
(Refereed journal article or data article (A1)) - Efficient radiosynthesis of a new folate receptor-targeting PET tracer, [18F]fluoronicotinic acid labeled folate, for imaging lung fibrosis (2023)
- Nuclear Medicine and Biology
(Other (O2)) - High folate receptor expression in gliomas can be detected in vivo using folate-based positron emission tomography with high tumor-to-brain uptake ratio divulging potential future targeting possibilities (2023)
- Frontiers in Immunology
(Refereed journal article or data article (A1)) - Macrophage Hitchhiking Nanoparticles for the Treatment of Myocardial Infarction: An In Vitro and In Vivo Study (2023)
- Advanced Functional Materials
(Refereed journal article or data article (A1)) - Mannose Receptor (CD206) Targeting with Aluminum Fluoride-18 Labeled Mannosylated Dextran (2023)
- Nuclear Medicine and Biology
(Other (O2)) - Pretargeted PET imaging of trans-cyclooctene functionalized spherical nucleic acids (2023)
- Nuclear Medicine and Biology
(Other (O2)) - Targeting mammary-derived growth inhibitor for positron emission tomography imaging of breast cancer brain metastasis (2023)
- Nuclear Medicine and Biology
Airaksinen Anu, Laakkonen Pirjo, Li Xiang-Guo
(Other (O2)) - Tetrazine Glycoconjugate for Pretargeted Positron Emission Tomography Imaging of trans-Cyclooctene-Functionalized Molecular Spherical Nucleic Acids (2023)
- ACS Omega
(Refereed journal article or data article (A1)) - Vascular adhesion protein-1-targeted PET imaging in autoimmune myocarditis (2023)
- Journal of Nuclear Cardiology
(Refereed journal article or data article (A1)) - 68Ga-Citrate Positron Emission Tomography of Healthy Men: Whole-Body Biodistribution Kinetics and Radiation Dose Estimates (2022)
- Journal of Nuclear Medicine
(Refereed journal article or data article (A1)) - Comparing Folate Receptor β Targeting Tracers in Experimental Myocarditis Model (2022)
- European Journal of Nuclear Medicine and Molecular Imaging
(Other (O2)) - Corrigendum: Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-18F-Fluoroglutamine(Front. Immunol., (2022), 13, (821423), 10.3389/fimmu.2022.821423) (2022)
- Frontiers in Immunology
(Other (O2)) - Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-F-18-Fluoroglutamine (2022)
- Frontiers in Immunology
(Refereed journal article or data article (A1)) - Exploring macrophage mannose receptor expression after myocardial infarction by Al[18F]F-NOTA-DCM positron emission tomography (2022)
- European Heart Journal
(Other (O2)) - [Ga-68]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice (2022)
- Frontiers in Immunology
(Refereed journal article or data article (A1)) - O-59 - Radiolabeling and biological evaluation of functionalized spherical nucleic acids (2022)
- Nuclear Medicine and Biology
(Other (O2)) - PET radiopharmaceuticals for imaging inflammatory diseases (2022) Nuclear Medicine and Molecular Imaging Li Xiang-Guo, Velikyan Irina, Viitanen Riikka, Roivainen Anne
(Refereed article in compilation book (A3)) - Preclinical Evaluation of a Humanized Antibody Against Common Lymphatic Endothelial and Vascular Endothelial Receptor-1, 89Zr-Desferrioxamine-Bexmarilimab, in a Rabbit Model of Renal Fibrosis (2022)
- Journal of Nuclear Medicine
(Refereed journal article or data article (A1))