Sirpa Jalkanen
Professor of Immunology, Academician

Professor, Institute of Biomedicine (Institute of Biomedicine)

sirjal@utu.fi
+358 29 450 4379
+358 40 566 9611

Tykistökatu 6
Turku
BioCity building MediCity 4th floor



Areas of expertise
Immunology, inflammation, cancer, drug development, biomarkers

Biography

Academician Sirpa Jalkanen is Academy Professor and Professorof Immunology at the Medical Faculty, University of Turku. After her postdoctoral period at Stanford University she has worked in different researcher positions at the University of Turku, Finnish National Institute of Health and Welfare as well as the Academy of Finland. Recently, she has also worked first as a vice chair and then as a chair of the Finnish Academy of Science and Letters. She is the director of the MediCity Research Laboratory (the Research Unit of the Medical Faculty, University of Turku). 

The main interest of Sirpa Jalkanen’s research group has been in the mechanisms mediating the cell trafficking in harmful inflammations and cancer. She has published more than 300 peer-reviewed papers and has more than 10 patents. She is an EMBO member and a member of Academia Europae and has received several awards and honours such as Eli Lilly award, Maud Kuistila Prize, Anders Jahre Prize, Äyräpää Prize, Datta Medal, and 2ndEuropean Women Innovator Prize and the Finnish Pharma Industry Prize. 

She has also several positions of trust. She is a member of the board in three big Finnish Foundations financing research In addition she is a member of the board of Orion, the biggest pharmaceutical company in Finland and has been a co-founder of two biotech companies.

 

 



Research

The overall goal of the research of the Jalkanen group is to elucidate the mechanisms regulating the traffic of leukocytes and cancer cells in the body. The focus is both on blood and lymphatic vasculature. Harmful leukocyte migration into the joints in rheumatoid arthritis and into the pancreas in diabetes are examples of diseases where leukocytes cause extensive destruction. These inflammatory diseases can be cured by inhibiting leukocyte trafficking. Also metastasising malignant cells often use the same mechanisms as leukocytes when extravasating from blood to different organs or migrating via the lymphatics into distant sites. The results obtained can be utilized when new types of drugs are developed to treat harmful inflammations and cancer. The group utilises the most modern imaging techniques, animal models, molecular and cell biology methods including single cell sequencing and mass cytometry and is intimately collaborating with clinicians.



Teaching

I have been teaching immunology for medical students since 1981. However, my main contribution is to train PhD students and postdoctoral fellows.



Publications
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Clever-1 contributes to lymphocyte entry into the spleen via the red pulp (2019)
Science Immunology
Tadayon S, Dunkel J, Takeda A, Halle O, Karikoski M, Gerke H, Rantakari P, Virtakoivu R, Pabst O, Salmi M, Hollmen M, Jalkanen S
(
A1 Journal article – refereed)

Immunotherapeutic Blockade of Macrophage Clever-1 Reactivates the CD8(+) T-cell Response against Immunosuppressive Tumors (2019)
Clinical Cancer Research
Viitala M., Virtakoivu R., Tadayon S., Rannikko J., Jalkanen S., Hollmen M.
(
A1 Journal article – refereed)

Safety Study of Single-Dose Intravenously Administered DOTA-Siglec-9 Peptide in Sprague Dawley Rats (2019)
International Journal of Toxicology
Chrusciel P, Yatkin E, Li XG, Jaakkola UM, Knuuti J, Jalkanen S, Roivainen A
(
A1 Journal article – refereed)

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage (2019)
Journal of Molecular Medicine
Julian Zeiner, Sirpa Loukovaara, Karolina Losenkova, Mariachiare Zuccarini, Ani M. Korhonen, Kaisa Lehti, Anu Kauppinen, Kai Kaarniranta, Christa E. Muller, Sirpa Jalkanen, Gennady G. Yegutkin
(
A1 Journal article – refereed)

Adventures in radiosynthesis of clinical grade [68Ga]Ga-DOTA-Siglec-9 (2018)
RSC Advances
Meeri Käkelä, Pauliina Luoto, Tapio Viljanen, Helena Virtanen, Heidi Liljenbäck, Sirpa Jalkanen, Juhani Knuuti, Anne Roivainen, Xiang-Guo Li
(
A1 Journal article – refereed)

Cell-type specific CD73 expression is an independent prognostic factor in bladder cancer (2018)
Carcinogenesis
Koivisto M, Tervahartiala M, Kenessey I, Jalkanen S, Boström PJ, Salmi M
(
A1 Journal article – refereed)

Chronic Active Arthritis Driven by Macrophages Without Involvement of T Cells A Novel Experimental Model of Rheumatoid Arthritis (2018)
Arthritis and Rheumatology
Hagert C, Sareila O, Kelkka T, Nandakumar KS, Collin M, Xu BZ, Guerard S, Backlund J, Jalkanen S, Holmdahl R
(
A1 Journal article – refereed)

Correlation between increasing tissue ischemia and circulating levels of angiogenic growth factors in peripheral artery disease (2018)
Cytokine
Jalkanen J., Hautero O., Maksimow M., Jalkanen S., Hakovirta H.
(
A1 Journal article – refereed)

Endothelial cells cope with hypoxia-induced depletion of ATP via activation of cellular purine turnover and phosphotransfer networks (2018)
BBA - Molecular Basis of Disease
Karolina Losenkova, Mariachiara Zuccarini, Mikko Helenius, Guillaume Jacquemet, Evgenia Gerasimovskaya, Camilla Tallgren, Sirpa Jalkanen, Gennady G. Yegutkin
(
A1 Journal article – refereed)

Enhanced Antibody Production in Clever-1/Stabilin-1-Deficient Mice (2018)
Frontiers in Immunology
Dunkel J, Viitala M, Karikoski M, Rantakari P, Virtakoivu R, Elima K, Hollmen M, Jalkanen S, Salmi M
(
A1 Journal article – refereed)

Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice. (2018)
PLoS ONE
Anniina Keskitalo, Eveliina Munukka, Raine Toivonen, Maija Hollmén, Heikki Kainulainen, Pentti Huovinen, Sirpa Jalkanen, Satu Pekkala
(
A1 Journal article – refereed)

Exploring Alternative Radiolabeling Strategies for Sialic Acid-Binding Immunoglobulin-Like Lectin 9 Peptide: [68Ga]Ga- and [18F]AlF-NOTA-Siglec-9 (2018)
Molecules
Moisio O, Siitonen R, Liljenbäck H, Suomela E, Jalkanen S, Li XG, Roivainen A.
(
A1 Journal article – refereed)

Mapping the interaction site and effect of the Siglec-9 inflammatory biomarker on human primary amine oxidase (2018)
Scientific Reports
Leonor Lopes de Carvalho, Heli Elovaara, Jerôme de Ruyck, Gerard Vergoten, Sirpa Jalkanen, Gabriela Guédez, Tiina A. Salminen
(
A1 Journal article – refereed)

Preoperative predictors for systemic inflammatory response in open-heart surgery (2018)
European Heart Journal
E Viikinkoski, M Hollmen, J Jalkanen, J Gunn, J Airaksinen, S Jalkanen, T Kiviniemi, CAREBANK
(
O2 Other)

Serum cytokine levels differ according to major cardiovascular risk factors in patients with lower limb atherosclerosis (2018)
Cytokine
Jalkanen J., Hollmén M., Maksimow M., Jalkanen S., Hakovirta H.
(
A1 Journal article – refereed)

Six-week endurance exercise alters gut metagenome that is not reflected in systemic metabolism in over-weight women (2018)
Frontiers in Microbiology
Eveliina Munukka, Juha P. Ahtiainen, Pere Puigbó, Sirpa Jalkanen, Katja Pahkala, Anniina Keskitalo, Urho M. Kujala, Sami Pietilä, Maija Hollmén, Laura Elo, Pentti Huovinen, Giuseppe D'Auria, Satu Pekkala
(
A1 Journal article – refereed)

The macrophage mannose receptor regulate mannan-induced psoriasis, psoriatic arthritis, and rheumatoid arthritis-like disease models (2018)
Frontiers in Immunology
Cecilia Hagert, Outi Sareila, Tiina Kelkka, Sirpa Jalkanen, Rikard Holmdahl
(
A1 Journal article – refereed)

Vascular adhesion protein-1 is actively involved in the development of inflammatory lesions in rat models of multiple sclerosis (2018)
Journal of Neuroinflammation
Elo P, Tadayon S, Liljenback H, Teuho J, Kakela M, Koskensalo K, Saunavaara V, Virta J, Veres TZ, Kiviniemi A, Saraste A, Marjamaki P, Airas L, Jalkanen S, Roivainen A
(
A1 Journal article – refereed)

Allergen-Induced CD4(+) T Cell Cytokine Production within Airway Mucosal Dendritic Cell-T Cell Clusters Drives the Local Recruitment of Myeloid Effector Cells (2017)
Journal of Immunology
Veres TZ, Kopcsanyi T, van Panhuys N, Gerner MY, Liu ZD, Rantakari P, Dunkel J, Miyasaka M, Salmi M, Jalkanen S, Germain RN
(
A1 Journal article – refereed)

Amine oxidase activity regulates the development of pulmonary fibrosis (2017)
FASEB Journal
Marttila-Ichihara F, Elima K, Auvinen K, Veres TZ, Rantakari P, Weston C, Miyasaka M, Adams D, Jalkanen S, Salmi M
(
A1 Journal article – refereed)


Last updated on 2019-17-08 at 02:17