Francisco Lopez Picon


Senior Researcher, PET Research (Turku PET Centre)

francisco.lopez@utu.fi
+358 29 450 3839
+358 50 356 2822

Tykistökatu 6
Turku





Publications
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Effect of genotype and age on cerebral [F-18]FDG uptake varies between transgenic APP(swe)-PS1(dE9) and Tg2576 mouse models of Alzheimer's disease (2019)
Scientific Reports
Anniina Snellman, Jatta S. Takkinen, Francisco R. López-Picón, Olli Eskola, Olof Solin, Juha O. Rinne, Merja Haaparanta-Solin
(
A1 Journal article – refereed)

In vivo characterization of a novel norepinephrine transporter PET tracer [18F]NS12137 in adult and immature Sprague-Dawley rats (2019)
Theranostics
López-Picón F, Kirjavainen AK, Forsback S, Takkinen JS, Peters D, Haaparanta-Solin M, Solin O
(
A1 Journal article – refereed)

Radiosynthesis and Preclinical Evaluation of an α2A-Adrenoceptor Tracer Candidate, 6-[18F]Fluoro-marsanidine (2019)
Molecular Imaging and Biology
Krzyczmonik A., Keller T., López-Picón F., Forsback S., Kirjavainen A.K., Takkinen J.S., Wasilewska A., Scheinin M., Haaparanta-Solin M., Solin O.
(
A1 Journal article – refereed)

[18F]F-DPA for the detection of activated microglia in a mouse model of Alzheimer's disease (2018)
Nuclear Medicine and Biology
Keller T, López-Picón FR, Krzyczmonik A, Forsback S, Kirjavainen AK, Takkinen JT, Alzghool O, Rajander J, Teperi S, Cacheux F, Damont A, Dollé F, Rinne JO, Solin O, Haaparanta-Solin M
(
A1 Journal article – refereed)

18F-labeled norepinephrine transporter tracer [18F]NS12137: radiosynthesis and preclinical evaluation (2018)
Nuclear Medicine and Biology
Anna K. Kirjavainen, Sarita Forsback, Francisco R. López-Picón, Päivi Marjamäki, Jatta Takkinen, Merja Haaparanta-Solin, Dan Peters, Olof Solin
(
A1 Journal article – refereed)

[F-18]FMPEP-d(2) PET imaging shows age- and genotype-dependent impairments in the availability of cannabinoid receptor 1 in a mouse model of Alzheimer's disease (2018)
Neurobiology of Aging
Jatta S. Takkinen, Francisco R. López-Picón, Anna K. Kirjavainen, Rea Pihlaja, Anniina Snellman, Tamiko Ishizu, Eliisa Löyttyniemi, Olof Solin, Juha O. Rinne, Merja Haaparanta-Solin
(
A1 Journal article – refereed)

Neuroinflammation appears early and then plateaus in a mouse model of Alzheimer's disease shown by PET imaging (2018) Francisco R. López-Picón, Anniina Snellman, Olli Eskola, Semi Helin, Olof Solin, Merja Haaparanta-Solin, Juha O. Rinne
(
A1 Journal article – refereed)

Applicability of [C-11]PIB micro-PET imaging for in vivo follow-up of anti-amyloid treatment effects in APP23 mouse model (2017)
Neurobiology of Aging
Snellman A, Rokka J, Lopez-Picon FR, Helin S, Re F, Löyttyniemi E, Pihlaja R, Forloni G, Salmona M, Masserini M, Solin O, Rinne JO, Haaparanta-Solin M
(
A1 Journal article – refereed)

Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal 18F-FDG and 18F-DPA-714 PET imaging (2017)
Journal of Cerebral Blood Flow and Metabolism
Jatta S Takkinen, Francisco R López-Picón, Rana Al Majidi, Olli Eskola, Anna Krzyczmonik, Thomas Keller, Eliisa Löyttyniemi, Olof Solin, Juha O Rinne, Merja Haaparanta-Solin
(
A1 Journal article – refereed)

Luminometric Nanoparticle-Based Assay for High Sensitivity Detection of β-Amyloid Aggregation (2017)
Analytical Chemistry
Sari Pihlasalo, Takahiro Deguchi, Maria Virtamo, Jenna Jacobino, Karthik Chary, Francisco R. López-Picón, Gerda Brunhofer-Bolzer, Roope Huttunen, Adyary Fallarero, Pia Vuorela, Harri Härmä
(
A1 Journal article – refereed)

Radiosynthesis and Preclinical Evaluation of [F-18]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats (2017)
Molecular Imaging and Biology
Keller T, Krzyczmonik A, Forsback S, Picon FRL, Kirjavainen AK, Takkinen J, Rajander J, Cacheux F, Damont A, Dolle F, Rinne JO, Haaparanta-Solin M, Solin O
(
A1 Journal article – refereed)

Ex Vivo Tracing of NMDA and GABA-A Receptors in Rat Brain After Traumatic Brain Injury Using F-18-GE-179 and F-18-GE-194 Autoradiography (2016)
Journal of Nuclear Medicine
Lopez-Picon F, Snellman A, Shatillo O, Lehtiniemi P, Gronroos TJ, Marjamaki P, Trigg W, Jones PA, Solin O, Pitkanen A, Haaparanta-Solin M
(
A1 Journal article – refereed)

Electrophilic fluorination and preclinical evaluation of a novel [F-18]DPA-714 analogue, [F-18]F-DPA (2015)
Journal of Labelled Compounds and Radiopharmaceuticals
Keller T, Krzyczmonik AM, Forsback S, Kirjavainen A, Lopez-Picon F, Cacheux F, Damont A, Dolle F, Haaparanta-Solin M, Solin O
(
O2 Other)

Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells (2015)
Journal of Neuroinflammation
Pihlaja R, Takkinen J, Eskola O, Vasara J, Lopez-Picon FR, Haaparanta-Solin M, Rinne JO
(
A1 Journal article – refereed)

In vivo PET imaging of beta-amyloid deposition in mouse models of Alzheimer's disease with a high specific activity PET imaging agent [18F]flutemetamol (2014)
EJNMMI Research
Anniina Snellman, Johanna Rokka, Francisco R López-Picón, Olli Eskola, Mario Salmona, Gianluigi Forloni, Mika Scheinin, Olof Solin, Juha O Rinne, Merja Haaparanta-Solin
(
A1 Journal article – refereed)

Brain uptake of novel NMDA and GABAergic PET tracers in a Model of Traumatic Brain Injury in Rat (2013)
European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging Picon FRL, Shatillo O, Snellman A, Jones PA, Trigg W, Lehtiniemi P, Marjamaki P, Solin O, Pitkanen A, Haaparanta-Solin M
(
O2 Other)

Longitudinal Amyloid Imaging in Mouse Brain with C-11-PIB: Comparison of APP23, Tg2576, and APP(swe)-PS1(dE9) Mouse Models of Alzheimer Disease (2013)
Journal of Nuclear Medicine
Snellman A, Lopez-Picon FR, Rokka J, Salmona M, Forloni G, Scheinin M, Solin O, Rinne JO, Haaparanta-Solin M
(
A1 Journal article – refereed)

Status epilepticus alters neurogenesis and decreases the number of GABAergic neurons in the septal dentate gyrus of 9-day-old rats at the early phase of epileptogenesis (2013)
Brain Research
Lauren HB, Ruohonen S, Kukko-Lukjanov TK, Virta JE, Gronman MA, Lopez-Picon FR, Jarvela JT, Holopainen IE
(
A1 Journal article – refereed)

Pharmacokinetics of [F-18]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer's disease (2012)
European Journal of Nuclear Medicine and Molecular Imaging
Snellman A, Rokka J, Lopez-Picon FR, Eskola O, Wilson I, Farrar G, Scheinin M, Solin O, Rinne JO, Haaparanta-Solin M
(
A1 Journal article – refereed)

Kainic acid-induced neurodegeneration and activation of inflammatory processes in organotypic hippocampal slice cultures: Treatment with cyclooxygenase-2 inhibitor does not prevent neuronal death (2011)
Neuropharmacology
Jarvela JT, Ruohonen S, Kukko-Lukjanov TK, Plysjuk A, Lopez-Picon FR, Holopainen IE
(
A1 Journal article – refereed)


Last updated on 2019-21-07 at 02:22