Tove Grönroos
Head of Preclinical PET Imaging
tovgro@utu.fi +358 29 450 3839 +358 50 356 2822 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0003-4468-0805 |
PET, cancer, energy metabolism, hypoxia, inflammation, experimental radiotherapy
Our translational research focuses on evaluating and validating PET tracers for imaging the tumor microenvironment. We are especially interested in approaches for determining the level of radioresistance in solid tumors that affect radiotherapy treatment outcomes in cancer patients. Such tracers can be utilized for treatment planning and follow-up purposes in clinical settings. Another objective is to re-evaluate some existing tracers for their possible use as cancer imaging tools or to measure changes in cancer-dependent metabolism pathways on a whole-body level, which might affect treatment outcomes. We combine PET technology with state-of-the-art technologies for molecular biology utilizing cell lines, tumor models, and patient-derived samples.
- Evaluation of PET imaging as a tool for detecting neonatal hypoxic-ischemic encephalopathy in a preclinical animal model (2024)
- Experimental Neurology
(Refereed journal article or data article (A1)) - [F-18]Fluoride uptake in various bone types and soft tissues in rat (2023)
- EJNMMI Research
(Refereed journal article or data article (A1)) - Small animal PET with spontaneous inhalation of 15O-labelled oxygen gases: Longitudinal assessment of cerebral oxygen metabolism in a rat model of neonatal hypoxic-ischaemic encephalopathy (2023)
- Journal of Cerebral Blood Flow and Metabolism
(Refereed journal article or data article (A1)) - TSPO is a potential independent prognostic factor associated with cellular respiration and p16 in head and neck squamous cell carcinoma (2023)
- Frontiers in Oncology
(Refereed journal article or data article (A1)) - Evaluation of [F-18]F-DPA PET for Detecting Microglial Activation in the Spinal Cord of a Rat Model of Neuropathic Pain (2022)
- Molecular Imaging and Biology
(Refereed journal article or data article (A1)) - Ovarian Cancers with Low CIP2A Tumor Expression Constitute an APR-246-Sensitive Disease Subtype (2022)
- Molecular Cancer Therapeutics
(Refereed journal article or data article (A1)) - Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon (2022)
- Cellular and Molecular Life Sciences
(Refereed journal article or data article (A1)) - CIP2A interacts with TopBP1 and drives basal-like breast cancer tumorigenesis (2021)
- Cancer Research
(Refereed journal article or data article (A1)) - Head and neck squamous cell carcinoma cell lines have an immunomodulatory effect on macrophages independent of hypoxia and toll-like receptor 9 (2021)
- BMC Cancer
(Refereed journal article or data article (A1)) - Intravenous transplantation of olfactory ensheathing cells reduces neuroinflammation after spinal cord injury via interleukin-1 receptor antagonist (2021)
- Theranostics
(Refereed journal article or data article (A1)) - More Than Meets the Eye: Scientific Rationale behind Molecular Imaging and Therapeutic Targeting of Prostate-Specific Membrane Antigen (PSMA) in Metastatic Prostate Cancer and Beyond (2021)
- Cancers
(Refereed review article in scientific journal (A2)) - Effects of Different Exercise Training Protocols on Gene Expression of Rac1 and PAK1 in Healthy Rat Fast- and Slow-Type Muscles (2020)
- Frontiers in Physiology
(Refereed journal article or data article (A1)) - Evaluation of [F-18]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy (2020)
- European Journal of Nuclear Medicine and Molecular Imaging
(Refereed journal article or data article (A1)) - Evaluation of image quality with four positron emitters and three preclinical PET/CT systems (2020)
- EJNMMI Research
(Refereed journal article or data article (A1)) - Preperitoneal Fat Grafting Inhibits the Formation of Intra-abdominal Adhesions in Mice (2020)
- Journal of Gastrointestinal Surgery
(Refereed journal article or data article (A1)) - [18F]SPA-RQ/PET Study of NK1 receptors in the Whole Body of Guinea Pig and Rat (2019)
- Scientific Reports
(Refereed journal article or data article (A1)) - Dovitinib dilactic acid reduces tumor growth and tumor-induced bone changes in an experimental breast cancer bone growth model (2019)
- Journal of Bone Oncology
(Refereed journal article or data article (A1)) - Synthesis of an Alkyne-Modified Bleomycin Disaccharide Precursor, Conversion to a F-18-Labeled Radiotracer, and Preliminary in vivo-PET Imaging Studies (2019)
- European Journal of Organic Chemistry
(Refereed journal article or data article (A1)) - Fat Grafting Can Induce Browning of White Adipose Tissue (2018)
- Plastic and Reconstructive Surgery Global Open
(Refereed journal article or data article (A1)) - Molecular design of radiocopper-labelled Affibody molecules (2018)
- Scientific Reports
(Refereed journal article or data article (A1))