Anne Roivainen
Professor of Preclinical Imaging and Drug Research

Professor, PET Basic Operations (Turku PET Centre)

aroivan@utu.fi


Turku PET Centre


Areas of expertise
Molecular Imaging; PET; Inflammation Imaging

Research

http://inflammation-imaging.utu.fi

Our group is based in Turku PET Centre, University of Turku and Turku University Hospital. Our research focuses on developing radiopharmaceuticals for the PET imaging of various inflammatory diseases.

Inflammation is a significant component of several chronic diseases involving the cardiovascular, metabolic, respiratory, gastro-intestinal, musculoskeletal and nervous systems. Positron emission tomography (PET) with targeted probes enables evaluation of the molecular and cellular pathophysiological mechanisms of diseases (i.e. molecular imaging). However, more specific markers than the currently used glucose analogue, fluorodeoxyglucose 18F-FDG, are needed to assess inflammation and its consequences in different pathologies. Aims of our studies are pre-clinical evaluation of new targeted probes and techniques for molecular imaging of inflammation. The imaging agents will be evaluated in experimental models of inflammation, in healthy subjects and in patients. The main hypothesis is that sensitive whole-body imaging of inflammation will enable early diagnosis, help in patient selection to particular therapy and monitor therapy outcome. Noteworthy, the development of new radiopharmaceuticals requires several years’ effort and expensive proof-of-concept and acute toxicity studies. Our research is focusing on PET tracers and to lesser extent magnetic resonance (MR) and single-photon emission computed tomography (SPECT) imaging agents.




Publications
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68Ga-DOTA chelate, a novel imaging agent for assessment of myocardial perfusion and infarction detection in a rodent model (2019)
Journal of Nuclear Cardiology
Anu Autio, Sauli Uotila, Max Kiugel, Ville Kytö, Heidi Liljenbäck, Nobuyuki Kudomi, Vesa Oikonen, Olli Metsälä, Semi Helin, Juhani Knuuti, Antti Saraste, Anne Roivainen
(
A1 Journal article – refereed)

Amyloid-Targeting PET Tracer [18F]Flutemetamol Accumulates in Atherosclerotic Plaques (2019) Hirani E., Morisson-Iveson V., Ylä-Herttuala S., Saukko P., Saraste A., Knuuti J., Roivainen A., Hellberg S., Silvola J., Liljenbäck H., Kiugel M., Eskola O., Hakovirta H., Hörkkö S.
(
A1 Journal article – refereed)

Determinants of Myocardial Strain in Experimental Chronic Myocardial Infarction (2019)
Ultrasound in Medicine and Biology
Haitham Ballo, Miikka Tarkia, Matti Haavisto, Christoffer Stark, Marjatta Strandberg, Tommi Vähäsilta, Virva Saunavaara, Tuula Tolvanen, Ville-Veikko Hynninen, Timo Savunen, Anne Roivainen, Juhani Knuuti, Antti Saraste
(
A1 Journal article – refereed)

Mesenchymal Cell-Derived Juxtacrine Wnt1 Signaling Regulates Osteoblast Activity and Osteoclast Differentiation (2019)
Journal of Bone and Mineral Research
Wang F., Tarkkonen K., Nieminen-Pihala V., Nagano K., Majidi R.A., Puolakkainen T., Rummukainen P., Lehto J., Roivainen A., Zhang F.-P., Mäkitie O., Baron R., Kiviranta R.
(
A1 Journal article – refereed)

Noninvasive and Quantitative Monitoring of the Distributions and Kinetics of MicroRNA-Targeting Molecules in Vivo by Positron Emission Tomography (2019)
Molecular Pharmaceutics
Jussi Mäkilä, Anu Kiviniemi, Tiina Saanijoki, Heidi Liljenbäck, Meeri Käkelä, Satish Jadhav, Päivi Poijärvi-Virta, Harri Lönnberg, Tiina Laitala-Leinonen, Pasi Virta, Anne Roivainen
(
A1 Journal article – refereed)

Rapid spread of mannan to the immune system, skin and joints within 6 hours after local exposure (2019)
Clinical and Experimental Immunology
Hagert C., Siitonen R., Li X., Liljenbäck H., Roivainen A., Holmdahl R.
(
A1 Journal article – refereed)

Safety Study of Single-Dose Intravenously Administered DOTA-Siglec-9 Peptide in Sprague Dawley Rats (2019)
International Journal of Toxicology
Chrusciel P, Yatkin E, Li XG, Jaakkola UM, Knuuti J, Jalkanen S, Roivainen A
(
A1 Journal article – refereed)

A Comparative 68Ga-Citrate and 68Ga-Chloride PET/CT Imaging of Staphylococcus aureus Osteomyelitis in the Rat Tibia (2018)
Contrast Media and Molecular Imaging
Petteri Lankinen, Tommi Noponen, Anu Autio, Pauliina Luoto, Janek Frantzèn, Eliisa Löyttyniemi, Antti J. Hakanen, Hannu T. Aro, Anne Roivainen
(
A1 Journal article – refereed)

Adventures in radiosynthesis of clinical grade [68Ga]Ga-DOTA-Siglec-9 (2018)
RSC Advances
Meeri Käkelä, Pauliina Luoto, Tapio Viljanen, Helena Virtanen, Heidi Liljenbäck, Sirpa Jalkanen, Juhani Knuuti, Anne Roivainen, Xiang-Guo Li
(
A1 Journal article – refereed)

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes (2018)
Diabetes
Natalie R. van Zuydam, Emma Ahlqvist, Niina Sandholm, Harshal Deshmukh, N. William Rayner,
Moustafa Abdalla, Claes Ladenvall, Daniel Ziemek, Eric Fauman, Neil R. Robertson,
Paul M. McKeigue, Erkka Valo, Carol Forsblom, Valma Harjutsalo, Finnish Diabetic
Nephropathy Study (FinnDiane), Annalisa Perna, Erica Rurali, M. Loredana Marcovecchio,
Robert P. Igo Jr., Rany M. Salem, Norberto Perico, Maria Lajer, Annemari Käräjämäki,
Minako Imamura, Michiaki Kubo, Atsushi Takahashi, Xueling Sim, Jianjun Liu,
Rob M. van Dam, Guozhi Jiang, Claudia H.T. Tam, Andrea O.Y. Luk, Heung Man Lee,
Cadmon K.P. Lim, Cheuk Chun Szeto, Wing Yee So, Juliana C.N. Chan,
Hong Kong Diabetes Registry Theme-based Research Scheme Project Group, Su Fen Ang,
Rajkumar Dorajoo, Ling Wang, Tan Si Hua Clara, Amy-Jayne McKnight, Seamus Duffy,
Warren and Genetics of Kidneys in Diabetes (GoKinD) Study Group, Marcus G. Pezzolesi,
GENIE (GEnetics of Nephropathy an International Effort) Consortium, Michel Marre, Beata Gyorgy,
Samy Hadjadj, Linda T. Hiraki, Diabetes Control and Complications Trial
(DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group,
Tarunveer S. Ahluwalia, Peter Almgren, Christina-Alexandra Schulz, Marju Orho-Melander,
Allan Linneberg, Cramer Christensen, Daniel R. Witte, Niels Grarup, Ivan Brandslund,
Olle Melander, Andrew D. Paterson, David Tregouet, Alexander P. Maxwell, Su Chi Lim,
Ronald C.W. Ma, E Shyong Tai, Shiro Maeda, Valeriya Lyssenko,
Tiinamaija Tuomi, Andrzej S. Krolewski, Stephen S. Rich, Joel N. Hirschhorn,
Jose C. Florez, David Dunger, Oluf Pedersen, Torben Hansen, Peter Rossing,
Giuseppe Remuzzi, SUrrogate markers for Micro- and Macrovascular
hard endpoints for Innovative diabetes Tools (SUMMIT) Consortium, Mary Julia Brosnan,
Colin N.A. Palmer, Per-Henrik Groop, Helen M. Colhoun, Leif C. Groop,
Mark I. McCarthy

(
A1 Journal article – refereed)

Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography (2018)
Scientific Reports
Johanna M. U. Silvola, Xiang-Guo Li, Jenni Virta, Päivi Marjamäki, Heidi Liljenbäck, Jarkko P. Hytönen, Miikka Tarkia, Virva Saunavaara, Saija Hurme, Senthil Palani, Harri Hakovirta, Seppo Ylä-Herttuala, Pekka Saukko, Qingshou Chen, Philip S. Low, Juhani Knuuti, Antti Saraste, Anne Roivainen
(
A1 Journal article – refereed)

Evaluation of [68Ga]Ga-DOTA-TCTP-1 for the Detection of Metalloproteinase 2/9 Expression in Mouse Atherosclerotic Plaques (2018)
Molecules
Kiugel M, Hellberg S, Käkelä M, Liljenbäck H, Saanijoki T, Li XG, Tuomela J, Knuuti J, Saraste A, Roivainen A
(
A1 Journal article – refereed)

Evaluation of 68Ga-labeled peptide tracer for detection of gelatinase expression after myocardial infarction in rat (2018)
Journal of Nuclear Cardiology
Kiugel M, Kytö V, Saanijoki T, Liljenbäck H, Metsälä O, Ståhle M, Tuomela J, Li XG, Saukko P, Knuuti J, Roivainen A, Saraste A
(
A1 Journal article – refereed)

Exploring Alternative Radiolabeling Strategies for Sialic Acid-Binding Immunoglobulin-Like Lectin 9 Peptide: [68Ga]Ga- and [18F]AlF-NOTA-Siglec-9 (2018)
Molecules
Moisio O, Siitonen R, Liljenbäck H, Suomela E, Jalkanen S, Li XG, Roivainen A.
(
A1 Journal article – refereed)

FDG-PET/CT(A) imaging in large vessel vasculitis and polymyalgia rheumatica: joint procedural recommendation of the EANM, SNMMI, and the PET Interest Group (PIG), and endorsed by the ASNC (2018)
European Journal of Nuclear Medicine and Molecular Imaging
Slart RHJA; Writing group; Reviewer group; Members of EANM Cardiovascular; Members of EANM Infection & Inflammation; Members of Committees, SNMMI Cardiovascular; Members of Council, PET Interest Group; Members of ASNC; EANM Committee Coordinator
(
A2 Review article in a scientific journal)

Glucagon-like peptide-1 receptor expression after myocardial infarction: Imaging study using [68Ga]NODAGA-exendin-4 positron emission tomography (2018)
Journal of Nuclear Cardiology
Mia Ståhle, Ville Kytö, Max Kiugel, Heidi Liljenbäck, Olli Metsälä, Meeri Käkelä, Xiang-Guo Li, Vesa Oikonen, Pekka Saukko, Pirjo Nuutila, Juhani Knuuti, Anne Roivainen, Antti Saraste
(
A1 Journal article – refereed)

In Vivo Imaging of Inflammation and Infection (2018)
Contrast Media and Molecular Imaging
Anne Roivainen, Xiang-Guo Li, Cristina Nanni, Weibo Cai, Sarah Ohrndorf
(
B1 Journal article)

In vivo imaging of Lyme arthritis in mice by [18F]fluorodeoxyglucose positron emission tomography/computed tomography (2018)
Scandinavian Journal of Rheumatology
A. Pietikäinen, R. Siitonen, H. Liljenbäck, O. Eskola, M. Söderström, A. Roivainen, J. Hytönen
(
A1 Journal article – refereed)

Morbid obesity and type 2 diabetes alter intestinal fatty acid uptake and blood flow (2018)
Diabetes, Obesity and Metabolism
Koffert J., Ståhle M., Karlsson H., Iozzo P., Salminen P., Roivainen A., Nuutila P.
(
A1 Journal article – refereed)

PET/CT to detect adverse reactions to metal debris in patients with metal-on-metal hip arthroplasty: an exploratory prospective study (2018)
Clinical Physiology and Functional Imaging
Aro E, Seppänen M, Mäkelä KT, Luoto P, Roivainen A, Aro HT
(
A1 Journal article – refereed)


Last updated on 2019-20-07 at 02:20