Jorma Toppari
MD, PhD

Professor, Institute of Biomedicine (Institute of Biomedicine)

jortop@utu.fi
+358 29 450 2826
+358 40 180 2600

Kiinamyllynkatu 10
Turku
Medisiina Kiinamyllynkatu 10
Office: C5 floor





Areas of expertise
Pediatric endocrinology; reproductive health; endocrine disruption; testis; type 1 diabetes

Biography



Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction. 



Research



The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.



Teaching

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology



Publications
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A Joint Modeling Approach for Childhood Meat, Fish and Egg Consumption and the Risk of Advanced Islet Autoimmunity (2019)
Scientific Reports
Essi Syrjälä, Jaakko Nevalainen, Jaakko Peltonen, Hanna-Mari Takkinen, Leena Hakola, Mari Åkerlund, Riitta Veijola, Jorma Ilonen, Jorma Toppari, Mikael Knip, Suvi M. Virtanen
(
A1 Journal article – refereed)

An update on semen quality among young Finnish men and comparison with Danish data (2019)
Andrology
Diabetologia
Rodprasert W, Virtanen HE, Sadov S, Perheentupa A, Skakkebaek NE, Jørgensen N, Toppari J
(
A1 Journal article – refereed)

Circulating CXCR5−PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes (2019)
Ilse Ekman, Emmi-Leena Ihantola, Tyyne Viisanen, Deepak A. Rao, Kirsti Näntö-Salonen, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Tuure Kinnunen
(
A1 Journal article – refereed)

Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes (2019) Lamichhane Santosh, Ahonen Linda, Dyrlund Thomas Spartholt, Dickens Alex M., Siljander Heli, Hyöty Heikki, Ilonen Jorma, Toppari Jorma, Veijola Riitta, Hyötyläinen Tuulia, Knip Mikael, Oresic Matej
(
A1 Journal article – refereed)

EAA clinical practice guidelines – gynecomastia evaluation and management (2019)
Andrology
G. A. Kanakis, L. Nordkap, A. K. Bang, A. E. Calogero, G. Bártfai, G. Corona, G. Forti, J. Toppari, D. G. Goulis, N. Jørgensen
(
A1 Journal article – refereed)

Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes (2019)
Pediatric Diabetes
Diabetes
Ilse Ekman, Tytti Vuorinen, Mikael Knip, Riitta Veijola, Jorma Toppari, Heikki Hyöty, Tuure Kinnunen, Jorma Ilonen, Johanna Lempainen
(
A1 Journal article – refereed)

FOXP3+Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children (2019)
Frontiers in Immunology
Tyyne Viisanen, Ahmad M. Gazali, Emmi-Leena Ihantola, Ilse Ekman, Kirsti Näntö-Salonen, Riitta Veijola, Jorma Toppari, Mikael Knip, Jorma Ilonen, Tuure Kinnunen
(
A1 Journal article – refereed)

Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families (2019)
Hippich M, Beyerlein A, Hagopian WA, Krischer JP, Vehik K, Knoop J, Winker C, Toppari J, Lernmark A, Rewers MJ, Steck AK, She JX, Akolkar B, Robertson CC, Onengut-Gumuscu S, Rich SS, Bonifacio E, Ziegler AG
(
A1 Journal article – refereed)

GnRH antagonist treatment of malignant adrenocortical tumors (2019)
Endocrine-Related Cancer
Doroszko M, Chrusciel M, Stelmaszewska J, Slezak T, Anisimowicz S, Plöckinger U, Quinkler M, Bonomi M, Wolczynski S, Huhtaniemi I, Toppari J, Rahman NA
(
A1 Journal article – refereed)

Letrozole versus testosterone for promotion of endogenous puberty in boys with constitutional delay of growth and puberty: a randomised controlled phase 3 trial (2019)
The Lancet. Child & adolescent health
Tero Varimo, Hanna Huopio, Laura Kariola, Sirpa Tenhola, Raimo Voutilainen, Jorma Toppari, Sanna Toiviainen-Salo, Esa Hämäläinen, Mari-Anne Pulkkinen, Mitja Lääperi, Annika Tarkkanen, Kirsi Vaaralahti, Päivi J Miettinen, Matti Hero, Taneli Raivio
(
A1 Journal article – refereed)

Low-saturated-fat and low-cholesterol diet does not alter pubertal development and hormonal status in adolescents (2019)
Acta Paediatrica
Sergey Sadov, Helena E. Virtanen, Katharina M. Main, Anna‐Maria Andersson, Anders Juul, Antti Jula, Olli T. Raitakari, Katja Pahkala, Harri Niinikoski, Jorma Toppari
(
A1 Journal article – refereed)

Maternal Dietary Supplement Use and Development of Islet Autoimmunity in the offspring: the TEDDY Study (2019)
Pediatric Diabetes
Silvis K, Aronsson CA, Liu X, Uusitalo U, Yang J, Tamura R, Lernmark Å, Rewers M, Hagopian W, She JX, Simell O, Toppari J, Ziegler A, Akolkar B, Krischer J, Norris JM, Virtanen SM, Norris JM; the TEDDY Study Group
(
A1 Journal article – refereed)

No Association Between Ljungan Virus Seropositivity and the Beta-Cell Damaging Process in the Finnish Type 1 Diabetes Prediction and Prevention Study Cohort (2019)
Pediatric Infectious Disease Journal
Jääskeläinen AJ, Nurminen N, Kolehmainen P, Smura T, Tauriainen S, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H, Vapalahti O, Kallio-Kokko H
(
A1 Journal article – refereed)

Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease. (2019)
Clinical and Translational Gastroenterology
Sen P, Carlsson C, Virtanen SM, Simell S, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M
(
A1 Journal article – refereed)

Populations, decreasing fertility, and reproductive health (2019)
Lancet
Skakkebaek NE, Jorgensen N, Andersson AM, Juul A, Main KM, Jensen TK, Toppari J
(
B1 Journal article)

Postnatal Testicular Activity in Healthy Boys and Boys With Cryptorchidism (2019)
Frontiers in Endocrinology
Tanja Kuiri-Hänninen, Jaakko Koskenniemi, Leo Dunkel, Jorma Toppari, Ulla Sankilampi
(
A2 Review article in a scientific journal)

Predicting islet cell autoimmunity and type 1 diabetes: An 8-year teddy study progress report (2019)
Diabetes Care
Jeffrey P. Krischer, Xiang Liu, Kendra Vehik, Beena Akolkar, William A. Hagopian, Marian J. Rewers, Jin-Xiong She, Jorma Toppari, Anette-G. Ziegler, Åke Lernmark; and the TEDDY Study Group
(
A1 Journal article – refereed)

Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children (2019)
Pediatric Diabetes
Jacobsen L.M., Larsson H.E., Tamura R.N., Vehik K., Clasen J., Sosenko J., Hagopian W.A., She J.-X., Steck A.K., Rewers M., Simell O., Toppari J., Veijola R., Ziegler A.G., Krischer J.P., Akolkar B., Haller M.J.; the TEDDY Study Group
(
A1 Journal article – refereed)

Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes (2019)
Journal of Clinical Endocrinology and Metabolism
Marjaana Mäkinen, Eliisa Löyttyniemi, Maarit Koskinen, Mari Vähä-Mäkilä, Heli Siljander, Mirja Nurmio, Juha Mykkänen, Suvi M Virtanen, Olli Simell, Heikki Hyöty, Jorma Ilonen, Mikael Knip, Riitta Veijola, Jorma Toppari
(
A1 Journal article – refereed)

Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children (2019)
Diabetes
Endesfelder D, Castell WZ, Bonifacio E, Rewers M, Hagopian WA, She JX, Lernmark Å, Toppari J, Vehik K, Williams AJK, Yu L, Akolkar B, Krischer JP, Ziegler AG, Achenbach P, Achenbach P; for the TEDDY Study Group
(
A1 Journal article – refereed)


Last updated on 2019-21-09 at 02:19